S1PC Blood Flow Improver Extraction and Purification
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Solution Overview
Problem
Current treatments for improving blood flow, such as those for cold sensitivity and stiff shoulder, often have side effects and are not mild in action, necessitating a more effective and safer solution.
Innovation Solution
A blood flow improver comprising S1PC or its salt, derived from Allium plants like garlic, onion, and Chinese chive, extracted using an aqueous ethanol solution and purified through cation exchange resin and chromatography, which improves blood flow with minimal side effects.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional treatments are used to improve blood flow, then blood circulation is improved, but side effects occur and the action is not mild
Solution Approach 1:
The invention extracts and isolates S1PC, a specific active ingredient from Allium plants, to create a targeted blood flow improver. This extraction approach allows for a purified compound that provides therapeutic effects with minimal side effects, resolving the contradiction between effectiveness and safety.
Solution Approach 2:
The invention specifies precise parameters for S1PC including chemical structure (Formula 1), purity (90% or more by HPLC), and trans-isomer content (50-100%). These parameter controls ensure the compound delivers blood flow improvement effects while maintaining mild action and minimal side effects.
2Manufacturing precision
If S1PC is extracted and purified through multiple steps, then purity and effectiveness are improved, but manufacturing complexity increases
Solution Approach 1:
The invention employs a multi-stage extraction and purification process including extraction with organic solvent, adsorption to cation exchange resin, and column chromatography. Each stage selectively removes impurities while concentrating S1PC, achieving high purity (90% or more by HPLC) despite the complex process.
Solution Approach 2:
The invention uses cation exchange resin as an intermediary material to facilitate purification. The resin selectively adsorbs S1PC from the extract, allowing separation from impurities. This intermediary approach enables effective purification while providing a systematic method to manage the complexity of the overall process.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The S1PC-based blood flow improver effectively relieves muscle fatigue, pain, and obstruction-related symptoms like cold sensitivity and stiff shoulder, offering a safe and long-term solution for improving blood circulation.
Implementation Method 1
Upon cutting, crushing, grating, or aging of garlic, the ingredient is converted by an enzyme called as γ-glutamyl transpeptidase contained in garlic, into water-soluble S-allylcysteine
Implementation Method 2
adsorbing the obtained extract to a cation exchange resin
Implementation Method 3
subjecting the eluate to a silica gel column chromatography and/or reverse phase column chromatography
Data Source
AI summary
Provided is a blood flow improver which is safe and has a mild action. The blood flow improver comprises S-1-propenylcysteine or a salt thereof as an active ingredient.