Sac-Shaped Cell Transplantation Kit for Immune Isolation

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Solution Overview

Problem

Current pancreatic islet transplantation methods face challenges such as immune rejection, low engraftment rates, and complications like embolization and bleeding due to insufficient blood flow at non-portal vein transplantation sites.

Innovation Solution

A cell transplantation kit is developed, comprising a first sac-shaped structure with minute pores that prevent immune cell invasion, and a second sac-shaped structure with larger diameters containing cells. This kit is transplanted into a living body to create a cell transplantation site with enhanced blood flow, allowing for improved engraftment and immune protection of heterologous cells.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If portal vein-mediated intrahepatic transplantation is used, then pancreatic islets can be transplanted, but a large number of transplanted islets are killed by immune reaction in short time and engraftment rate is low

Engineering Contradiction:

Improveengraftment rateVSAvoidimmune reaction

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent introduces an immunity isolating membrane as an intermediary barrier between the transplanted pancreatic islets and the host immune system. This membrane selectively blocks immune cells and antibodies from attacking the islets while allowing nutrients and oxygen to pass through, thereby protecting the islets from immune rejection and improving engraftment rate

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The patent employs a thin film-like immunity isolating membrane that can be easily integrated with the transplantation site. This flexible membrane structure provides physical protection to the islets while maintaining tissue compatibility and allowing for successful transplantation

Inventive Principle:

Principle #30Flexible shells and thin films

2Ease of operation

If intravascular transplantation is carried out, then pancreatic islets can be transplanted, but problems such as embolization and bleeding occur

Engineering Contradiction:

Improvetransplantation procedureVSAvoidembolization and bleeding

Core Design Contradiction:

Ease of operationVSObject-affected harmful factors

Solution Approach 1:

The immunity isolating membrane acts as a protective intermediary that prevents direct contact between the transplanted islets and the vascular system, thereby eliminating the risks of embolization and bleeding associated with intravascular transplantation while maintaining the benefits of the procedure

Inventive Principle:

Principle #24Intermediary (Mediator)

3Ease of operation

If subcutaneous site is used for transplantation, then transplantation can be performed, but blood flow is insufficient and engraftment rate is low

Engineering Contradiction:

Improvetransplantation site accessibilityVSAvoidengraftment rate

Core Design Contradiction:

Ease of operationVSReliability

Solution Approach 1:

The immunity isolating membrane serves as a protective intermediary that enables the use of subcutaneous sites for transplantation by providing immune protection to the islets, thereby overcoming the insufficient blood flow problem while maintaining high engraftment rate through selective immune blocking

Inventive Principle:

Principle #24Intermediary (Mediator)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The kit achieves high engraftment rates and prolonged medical treatment effects by creating a protected environment for transplanted cells, reducing immune rejection, and allowing for easy removal, addition, or exchange of cells.

Implementation Method 1

a first sac-shaped structure consisting of a membrane having pores of an average pore diameter of 0.2 mm or less

Methodology Applied

Scientific EffectPhysical barrier: Physical Containment

Implementation Method 2

creating a protected environment for transplanted cells, reducing immune rejection

Methodology Applied

Scientific EffectImmune isolation: Physical Containment

Data Source

PatentEP3903881B1Cell transplant kit and method for manufacturing the kit

Publication Date: 2025.04.30 FUJIFILM CORP

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AI summary

An object of the present invention is to provide a cell transplantation kit capable of exhibiting a high medical treatment effect by transplanted cells, a method for producing a sac-shaped structure that is used in the cell transplantation kit, and a therapeutic agent for diabetes containing the cell transplantation kit. According to the present invention, there is provided a cell transplantation kit including a first sac-shaped structure consisting of a membrane having pores of an average pore diameter of 0.2 mm or less, and a plurality of second sac-shaped structures having an average long diameter larger than the average pore diameter of the pores of the first sac-shaped structure, in which at least a part of the plurality of second sac-shaped structures contain cells. According to the present invention, there is provided a method for producing a sac-shaped structure that is used in the cell transplantation kit. According to the present invention, there is provide a therapeutic agent for diabetes, including the cell transplantation kit.