Saccharide Acid Composition for Disease Model Simulation
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Solution Overview
Problem
Current methods for simulating human diseases in animal models fail to accurately replicate normal human eating habits, limiting the effectiveness of drug screening and treatment for diseases like cancer, cardiovascular diseases, and diabetes, as the etiology of these diseases remains unclear.
Innovation Solution
A composition comprising a saccharide, such as glucose, and an acid, like phosphoric acid, hydrochloric acid, or lactic acid, in specific ratios, is used to create animal models that simulate human diseases, allowing for the induction of conditions like cancer and cardiovascular diseases, facilitating drug screening and treatment development.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If conventional animal models are used for disease simulation, then the model preparation is simple, but the accuracy of simulating human disease states is insufficient
Solution Approach 1:
The patent changes the chemical parameters of the feeding composition by incorporating specific acids (phosphoric acid, hydrochloric acid, lactic acid) in controlled amounts alongside saccharides. This parameter modification enables the composition to induce disease states more accurately resembling human pathology, transforming a simple dietary model into a precise disease simulation system.
Solution Approach 2:
The patent creates a composite feeding composition combining multiple components: saccharides (glucose, fructose, sucrose), organic acids (acetic acid, citric acid), inorganic acids (phosphoric acid, hydrochloric acid, lactic acid), and other nutrients. This composite material approach allows the composition to simultaneously provide nutrition and induce specific disease states, achieving both feeding function and disease modeling accuracy.
2Reliability
If complex compositions are used to improve disease simulation accuracy, then the etiology understanding improves, but the preparation complexity increases
Solution Approach 1:
The patent establishes specific parameter ranges for acid concentrations (0.1-5% for organic acids, 0.01-2% for inorganic acids) and saccharide ratios to achieve reliable disease induction. By defining these parameters, the complex composition becomes systematically preparable with controlled variability, balancing reliability with manufacturability.
Solution Approach 2:
The patent creates a universal feeding composition formula that can induce multiple disease states (diabetes, obesity, cardiovascular disease, cancer) through a single multi-component formulation. This multi-functional composition reduces the need for separate complex preparations for different diseases, improving ease of manufacture while maintaining high reliability across various disease models.
3Productivity
If accurate human eating habits are simulated, then drug screening effectiveness improves, but the time and resources required increase
Solution Approach 1:
The patent prepares standardized feeding compositions in advance with pre-determined acid and saccharide ratios that are known to induce specific disease states. This preliminary preparation of standardized formulations eliminates the need for complex real-time adjustments during drug screening, reducing time loss while maintaining high screening effectiveness through consistent, reproducible disease models.
Solution Approach 2:
The patent optimizes the parameters of the feeding composition to achieve rapid disease induction within 4-12 weeks, significantly shorter than traditional models. By adjusting acid concentrations and saccharide types, the composition accelerates disease development, thereby improving drug screening productivity without requiring excessive time investment in model preparation and maintenance.
Data Source
AI summary
A composition and a use thereof are provided. The composition includes a saccharide and an acid or a saccharide, an acid, and an alcohol. The composition may be used to prepare animal models simulating various human diseases, and thus used for prevention and treatment of human diseases and screening of drugs.