Sustained-Release Saccharide Composition for pH-Independent Glucose Control
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Solution Overview
Problem
Existing saccharide compositions face challenges in achieving stable, pH-independent sustained release due to individual differences in gastrointestinal pH and solubility, and issues with hygroscopicity and compressibility, leading to inconsistent dissolution effects and poor product stability.
Innovation Solution
A sustained-release saccharide composition comprising saccharides like glucose or maltose with a combination of hydroxypropyl methylcellulose and sodium alginate as sustained-release agents, along with film-forming agents and anti-adherents, to achieve controlled release and stability, formulated into tablets or granules.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Duration of action of moving object
If hydrophobic polymers are added to modulate saccharide release, then sustained-release effect is achieved, but pH dependence causes individual differences in release consistency
Solution Approach 1:
The patent changes the chemical composition parameter of the sustained-release agent from pH-sensitive hydrophobic polymers to pH-insensitive materials (sodium carboxymethylcellulose, hydroxypropyl cellulose, hydroxypropyl methylcellulose). This parameter change eliminates pH dependence while maintaining the sustained-release function, ensuring consistent release across different gastrointestinal conditions.
Solution Approach 2:
The patent uses composite sustained-release agents combining multiple cellulose derivatives (sodium carboxymethylcellulose, hydroxypropyl cellulose, hydroxypropyl methylcellulose) with specific viscosity ranges. This composite approach leverages the complementary properties of each material to achieve both sustained-release and pH-independence, resolving the contradiction between release duration and reliability.
2Manufacturing precision
If saccharides with high solubility are used, then rapid dissolution is achieved, but complete absorption occurs too quickly to prevent nocturnal hypoglycemia
Solution Approach 1:
The patent introduces sustained-release agents as intermediary materials that mediate between the saccharide core and the gastrointestinal environment. These agents form a controlled-release matrix that allows water penetration and saccharide dissolution while maintaining a sustained release rate, thus extending blood glucose control duration without compromising dissolution efficiency.
Solution Approach 2:
The patent changes the physical state parameter of saccharides from pure crystalline forms to controlled-release matrix forms embedded in sustained-release agents. This parameter change transforms rapid dissolution into sustained dissolution, extending the duration of blood glucose control while maintaining adequate dissolution speed for nutritional absorption.
3Quantity of substance
If common foods are ingested before sleeping, then blood glucose can be supplemented, but individual differences in digestion and absorption make control unstable
Solution Approach 1:
The patent applies local quality by designing a specialized pharmaceutical composition with controlled physical and chemical properties tailored for nocturnal hypoglycemia prevention. Unlike common foods with variable composition, this product has standardized saccharide content, controlled particle size, and specific sustained-release agent ratios, ensuring consistent dissolution and absorption characteristics across different users.
Solution Approach 2:
The patent creates a universal product that addresses the limitations of common foods by incorporating multiple functional components: saccharides for glucose supplementation, sustained-release agents for controlled dissolution, and formulations designed for consistent performance. This multi-functional composition provides reliable blood glucose control regardless of individual differences in digestion and absorption.
4Quantity of substance
If saccharides are highly hygroscopic, then they absorb water easily, but particle size increases and dissolution properties change
Solution Approach 1:
The patent introduces hydrophobic sustained-release agents (hydroxypropyl cellulose, hydroxypropyl methylcellulose) as intermediary materials that form a protective matrix around hygroscopic saccharides. This matrix allows controlled water penetration for dissolution while preventing excessive water absorption that would cause particle swelling and dissolution property changes, thus maintaining dissolution consistency.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition provides a stable, pH-independent sustained release profile, effectively controlling blood glucose levels overnight, preventing nocturnal hypoglycemia by ensuring gradual saccharide release over 24 hours, suitable for diabetic patients.
Implementation Method 1
a sustained-release saccharide composition, comprising a saccharide and a sustained-release agent
Implementation Method 2
achieve controlled release and stability, formulated into tablets or granules
Implementation Method 3
Saccharides (such as maltose) are highly hygroscopic, and may easily absorb water even at a low relative humidity (e.g., a relative humidity of 40%), resulting in increased particle size
Implementation Method 4
it is necessary to select a suitable coating formulation and production process to compensate for the disadvantages of physical properties
Implementation Method 5
achieve the sustained release of saccharides in the human body... pH-dependent... Therefore the pH dependence of such hydrophobic polymers added for modulating sustained saccharide release may result in individual differences
Data Source
AI summary
A saccharide sustained-release composition and a preparation method therefor. Provided is the saccharide sustained-release composition. The composition comprises a saccharide substance and a sustained-release agent, the sustained-release agent comprising at least two selected from hydroxypropyl methylcellulose, sodium alginate, cellulose, methyl cellulose, ethyl cellulose, microcrystalline cellulose, carboxymethyl cellulose, sodium carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, polyethylene oxide, a carboxyvinyl polymer, polyoxyethylene, a polyvinyl acetate aqueous dispersion, glycerol monooleate, glycerol monostearate, a carbomer homopolymer, a carbomer interpolymer, carrageenan, shellac, guar gum, xanthan gum, alginic acid and starch.