SAIB Solvent System for Controlled Release
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Solution Overview
Problem
Biodegradable systems for controlled release of medicinally active substances face challenges due to the high viscosity of sucrose acetate isobutyrate (SAIB), requiring dilution with solvents for parenteral administration, and existing solvents may not provide optimal solvency for all active ingredients.
Innovation Solution
The use of glycerol formal and Solketal as solvents with SAIB in biodegradable pharmaceutical systems, which improves solvency for active ingredients like fluoroquinolones and analgesics, allowing for controlled release formulations with varying release characteristics by adjusting SAIB concentrations.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Duration of action of moving object
If SAIB is used as active ingredient carrier, then controlled release is achieved, but high viscosity requires dilution with solvent
Solution Approach 1:
The patent changes the chemical composition parameters of the solvent system by selecting specific solvents (glycerol formal, Solketal, ethyl lactate) with appropriate solubility characteristics for SAIB and active ingredients. This parameter optimization enables the formulation to achieve both adequate viscosity for controlled release and sufficient fluidity for parenteral administration without requiring excessive dilution.
2Duration of action of moving object
If SAIB concentration is increased for sustained release, then release duration is extended, but formulation becomes more viscous and harder to administer
Solution Approach 1:
The patent creates a composite solvent system combining glycerol formal and/or Solketal with ethyl lactate in specific ratios. This composite approach leverages the complementary properties of each solvent: glycerol formal and Solketal provide high solvency for SAIB and active ingredients, while ethyl lactate contributes to fluidity and injectability. The synergistic combination enables sustained release formulations with optimized administration characteristics.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This combination enhances the solubility and stability of active ingredients, enabling effective controlled release formulations with improved tolerability and stability, particularly for fluoroquinolones and analgesics, and allows for adjustments in release profiles through SAIB concentration variations.
Implementation Method 1
Addition of glycerol formal and/or Solketal improves the solvency for many active ingredients
Data Source
AI summary
The invention relates to a system for controlled release of medicinally active substances, which comprises sucrose acetate isobutyrate (SAIB) and a further solvent.