Salacia Extract Suppressing Pathogenic Intestinal Bacteria
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Solution Overview
Problem
Current methods do not effectively suppress the number of intestinal bacteria associated with diseases, particularly those from the families Lachnospiraceae, Ruminococcaceae, Fusobacteriaceae, and Desulfovibrionaceae, which are linked to inflammatory bowel diseases and other gastrointestinal issues.
Innovation Solution
An extract or crushed product of the genus Salacia, such as Salacia reticulata or Salacia oblonga, is used to suppress the population of these bacteria, administered orally in the form of a food or pharmaceutical product, altering the intestinal flora to alleviate symptoms and prevent disease.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If conventional methods are used to adjust intestinal flora, then the proportion of Bacteroidetes increases and Firmicutes decreases, but the number of pathogenic bacteria associated with diseases (Lachnospiraceae, Ruminococcaceae, Fusobacteriaceae, and Desulfovibrionaceae) is not effectively suppressed
Solution Approach 1:
The patent changes the parameter of bacterial suppression from general flora adjustment to specific pathogenic bacteria targeting. By using Salacia extract, the method specifically suppresses the number of bacteria from families Lachnospiraceae, Ruminococcaceae, Fusobacteriaceae, and Desulfovibrionaceae, which are associated with inflammatory bowel diseases, while maintaining the beneficial effect of increasing Bacteroidetes proportion.
2Quantity of substance
If the intestinal flora is adjusted to increase Bacteroidetes and decrease Firmicutes, then body weight control is improved, but disease-associated bacteria are not targeted
Solution Approach 1:
The patent applies local quality by differentiating the treatment approach for different bacterial groups. Instead of uniform flora adjustment, it specifically targets pathogenic bacteria families (Lachnospiraceae, Ruminococcaceae, Fusobacteriaceae, Desulfovibrionaceae) associated with inflammatory bowel diseases, while maintaining the beneficial overall flora composition with increased Bacteroidetes.
3Adaptability or versatility
If general intestinal flora adjustment is performed, then overall gut health is improved, but specific disease prevention and treatment capabilities are not achieved
Solution Approach 1:
The patent segments the intestinal bacteria into beneficial groups (Bacteroidetes) and pathogenic groups (Lachnospiraceae, Ruminococcaceae, Fusobacteriaceae, Desulfovibrionaceae). By using Salacia extract, it selectively suppresses the pathogenic segments while maintaining or enhancing the beneficial segments, achieving both flora balance and disease-specific treatment.
Data Source
AI summary
An object of the present invention is to provide an agent for suppressing the number of intestinal bacteria, which is capable of suppressing the number of particular intestinal bacteria associated with a disease, and a food and pharmaceutical product containing the agent for suppressing the number of intestinal bacteria. The present invention provides an agent for suppressing the number of intestinal bacteria, which contains an extract and/or crushed product of a plant of the genus Salacia, wherein the intestinal bacterium is at least one which is selected from the group consisting of the families Lachnospiraceae, Ruminococcaceae, Fusobacteriaceae, and Desulfovibrionaceae.