Giant Salamander Cartilage Enzymatic Extract for Uric Acid Reduction
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Solution Overview
Problem
The unsustainable use of shark cartilage for medicinal and health supplements due to overfishing and the decline of shark populations, leading to environmental concerns and market limitations.
Innovation Solution
Development of Andrias davidianus cartilage enzymatic extract, comprising chondroitin sulfate and crude cartilage polypeptide extract, obtained through proteolysis and alcohol precipitation, which can be used to create a medicament for reducing uric acid and treating hyperuricemia or gout.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If shark cartilage is used for medicinal and health supplements, then anti-tumor, anti-angiogenesis, immune regulation, and anti-arthritis activities are achieved, but shark populations decline and environmental sustainability is compromised
Solution Approach 1:
The patent replaces shark cartilage with giant salamander cartilage, using a different biological source that is more sustainable and environmentally friendly while maintaining similar medicinal properties
Solution Approach 2:
The patent modifies the cartilage preparation process by controlling proteolysis conditions (enzyme type, temperature, pH, time) to optimize the extraction of active components, transforming the cartilage into an enzymatic extract with enhanced medicinal activity
2Productivity
If shark cartilage market develops, then demand for cartilage products increases, but shark fishing amount increases and shark populations drop sharply
Solution Approach 1:
The patent substitutes shark cartilage with giant salamander cartilage, which is abundant and sustainably available, thereby meeting market demand without depleting shark populations
Solution Approach 2:
The patent recovers and utilizes giant salamander cartilage, a byproduct of the salamander industry, transforming it into a valuable medicinal product that replaces shark cartilage in the market
3Productivity
If Andrias davidianus cartilage is processed, then sustainable biological resources are provided, but complex extraction and purification processes are required
Solution Approach 1:
The patent divides the cartilage extraction process into distinct stages: proteolysis to break down cartilage proteins, alcohol precipitation to separate and purify active components, and freeze-drying to final product formation. This segmentation makes the complex process more manageable and scalable
Solution Approach 2:
The patent optimizes extraction parameters including protease type and concentration, temperature, pH level, alcohol concentration, and drying conditions to maximize yield and purity of active components while minimizing process complexity
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The Andrias davidianus cartilage enzymatic extract demonstrates anti-tumor, anti-angiogenesis, anti-inflammatory, anti-oxidation, immuno-enhancement, anti-osteoporosis, anti-rheumatic, and uric acid-lowering activities, providing a sustainable alternative to shark cartilage products.
Implementation Method 1
proteolyzing the obtained cartilage
Implementation Method 2
alcohol-precipitating the proteolyzed supernatant
Data Source
AI summary
Disclosed is an Andrias davidianus cartilage preparation. The Andrias davidianus cartilage enzymatic extract of the present invention is obtained by a method comprising: obtaining cartilage from Andrias davidianus, proteolyzing the obtained cartilage, obtaining a supernatant after the proteolysis, and drying the supernatant. The Andrias davidianus cartilage enzymatic extract and an alcohol-soluble component thereof according to the present invention comprise a cartilage polypeptide, and have the effects of lowering uric acid, or treating hyperuricemia.