Bivalent Metal Salen Complex Radical Inhibitor

Resolve Bottlenecks,
Find Innovative Solutions
Generate Solutions

Solution Overview

Problem

Current radical scavengers provide temporary inhibition of radical generation, leading to product deterioration and adverse health effects, necessitating a more effective radical inhibition solution.

Innovation Solution

A bivalent metal complex compound, specifically a metal-salen complex, is used to trap free radicals, offering a long-lasting inhibition effect in various compositions such as cosmetics, medical, and food products, with a notable weight ratio of 3-5:7-5 with hydrated crystal neotrehalose.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If a radical scavenger is used to inhibit radical generation, then radical responsiveness is prevented or inhibited, but the radical inhibiting effect does not continue for a long period of time

Engineering Contradiction:
Improveradical inhibiting effectVSAvoidduration of radical inhibition
Core Design Contradiction:
ReliabilityVSDuration of action of stationary object

Solution Approach 1:

The patent changes the chemical parameters of the radical inhibition system by using bivalent metal complexes with specific ligands (salen, porphyrin, phthalocyanine) instead of conventional organic radical scavengers. This parameter change results in a metal-centered radical trap that provides sustained inhibition over time, resolving the contradiction between effectiveness and duration.

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The invention employs composite metal complex structures comprising bivalent metal ions coordinated with specific organic ligands. These composite materials exhibit enhanced and prolonged radical trapping capabilities compared to simple organic scavengers, thereby extending the duration of radical inhibition while maintaining high reliability.

Inventive Principle:
Principle #40Composite materials

2Object-affected harmful factors

If conventional radical scavengers are used, then radical responsiveness is inhibited temporarily, but product deterioration and adverse health effects still occur over time

Engineering Contradiction:
Improveradical damage to products and healthVSAvoidlong-term protection duration
Core Design Contradiction:
Object-affected harmful factorsVSDuration of action of stationary object

Solution Approach 1:

The bivalent metal complex acts as an intermediary substance that mediates between radicals and the protected substrates (products or biological systems). The metal center serves as a stable intermediate trap for radicals, preventing them from attacking other molecules, thereby providing long-term protection against radical-induced damage.

Inventive Principle:
Principle #24Intermediary (Mediator)

Solution Approach 2:

The patent replaces short-lived organic radical scavengers with stable, reusable metal complex systems. The metal centers can undergo multiple cycles of radical trapping and regeneration, effectively replacing disposable scavengers with durable, long-lasting protective agents.

Inventive Principle:
Principle #27Cheap short-living objects (Disposable)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The metal-salen complex effectively inhibits radical progression, maintaining product quality and human health by trapping free radicals, including those from active enzymes, and demonstrates anticancer properties without the need for a magnetic carrier.

Implementation Method 1

a metal complex compound of a bivalent metal of formula (1) as defined in the claims has a notable radical inhibiting action, thereby devising the invention of this application. Specifically speaking, disclosed herein is a radical inhibitor containing a bivalent metal complex compound as a radical inhibiting component. Free radicals such as active enzymes are trapped by a bivalent metal such as a bivalent metal coordinated by salen.

Methodology Applied
Scientific EffectCoordination bonding: Chemical Bonding

Data Source

PatentEP2772522B1Radical inhibitor
Publication Date: 2020.05.27 IHI CORP
  • EP2772522B1 patent drawing
  • EP2772522B1 patent drawing
  • EP2772522B1 patent drawing

AI summary

A new radical inhibitor, a composition containing the new radical inhibitor, and a radical generation inhibition method using the new radical inhibitor are provided. A radical inhibitor according to the present invention contains a salen complex compound of a bivalent metal.