Saline Electrolyte Solution for Enteral Infusion

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Solution Overview

Problem

Existing electrolyte solutions for enteral and parenteral administration fail to adequately match the macronutrient composition of blood plasma, leading to water-electrolyte disturbances, hyperchloremic metabolic acidosis, and other complications in intensive care patients.

Innovation Solution

A saline electrolyte solution (SES) is developed for enteral infusions, comprising sodium chloride, potassium chloride, sodium acetate, sodium phosphate, calcium chloride, magnesium sulfate, and other components, designed to mimic the ionic composition and pH of fasting chyme in the small intestine.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If electrolyte solutions are designed to match blood plasma composition, then electrolyte balance is improved, but manufacturing complexity increases due to the difficulty of achieving perfect macroelement composition matching

Engineering Contradiction:
Improveelectrolyte balanceVSAvoidmanufacturing complexity
Core Design Contradiction:
ReliabilityVSEase of manufacture

Solution Approach 1:

The patent modifies the electrolyte composition parameters by using acetate and phosphate buffers instead of traditional chloride-based buffers, adjusting the macroelement ratios to better match physiological conditions while remaining manufacturable. This changes the chemical parameters of the solution to achieve better electrolyte balance without excessive manufacturing complexity

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The patent creates a composite electrolyte solution combining multiple buffer systems (acetate and phosphate) with specific ratios of sodium, potassium, calcium, and magnesium ions. This composite approach allows the solution to match blood plasma composition more closely while maintaining manufacturing feasibility through standardized preparation protocols

Inventive Principle:
Principle #40Composite materials

2Reliability

If chloride concentration is increased to match physiological saline, then osmolarity is improved, but hyperchloremic metabolic acidosis occurs

Engineering Contradiction:
ImproveosmolarityVSAvoidhyperchloremic metabolic acidosis
Core Design Contradiction:
ReliabilityVSObject-generated harmful factors

Solution Approach 1:

The patent converts the harmful effect of high chloride concentration by replacing it with acetate and phosphate buffers that provide similar osmotic pressure without causing acidosis. The acetate buffer is metabolized to bicarbonate, which actually helps correct acid-base balance rather than worsen it

Inventive Principle:
Principle #22Blessing in disguise (Convert harm into benefit)

Solution Approach 2:

The patent changes the buffer composition parameters by using acetate (20-40 mmol/L) and phosphate (5-20 mmol/L) instead of high chloride concentrations, maintaining appropriate osmolarity (285-310 mOsm/L) while eliminating the harmful hyperchloremic effect

Inventive Principle:
Principle #35Parameter changes

3Reliability

If macroelement composition is optimized to match blood plasma, then water-electrolyte balance is improved, but solution stability deteriorates due to precipitation risks

Engineering Contradiction:
Improvewater-electrolyte balanceVSAvoidsolution stability
Core Design Contradiction:
ReliabilityVSStability of the object's composition

Solution Approach 1:

The patent adjusts the concentration parameters of calcium (2-5 mmol/L) and phosphate (5-20 mmol/L) to levels that match physiological requirements while remaining below the precipitation threshold. The acetate buffer system is used to maintain pH (7.35-7.45) at levels that prevent calcium phosphate precipitation

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The patent introduces acetate and phosphate as intermediary buffer substances that mediate between the requirement for physiological electrolyte balance and the need for solution stability. These buffers maintain pH and ionic strength while preventing direct precipitation of calcium salts

Inventive Principle:
Principle #24Intermediary (Mediator)

4Productivity

If electrolyte concentration is increased to cover losses, then compensation efficiency is improved, but intestinal absorption capacity is exceeded causing disturbances

Engineering Contradiction:
Improvecompensation efficiencyVSAvoidintestinal absorption
Core Design Contradiction:
ProductivityVSReliability

Solution Approach 1:

The patent uses partial action by providing electrolytes at concentrations that are sufficient to cover normal physiological losses but below the threshold that would overwhelm intestinal absorption capacity. The solution is designed for gradual rehydration rather than rapid volume expansion

Inventive Principle:
Principle #16Partial or excessive action

Solution Approach 2:

The patent optimizes the osmolarity parameter to 285-310 mOsm/L, which matches physiological levels and ensures optimal intestinal absorption. The electrolyte concentrations are adjusted to provide adequate compensation without exceeding transport maximums for intestinal uptake

Inventive Principle:
Principle #35Parameter changes

Data Source

PatentUS20250057953A1Electrolyte composition for introduction into a human digestive tract, balanced in macroelement compound and PH with a mural chymus of initial parts of the small intestine
Publication Date: 2025.02.20 VORONOV ALEKSEI VLADIMIROVICH

AI summary

The chyme-adapted saline electrolyte solution for administering enteral infusions includes sodium chloride, potassium chloride, sodium acetate, sodium phosphate, calcium chloride, magnesium sulfate, water at the following ions ratio, wt. %: sodium 12.4-35.4—potassium 2.5-15.6—calcium 0.65-7.785—magnesium 0.45-4.671—chlorine 20.4-48.65—phosphate 3.1-34.4—sulphate 0.28-13.27—acetate to 23.27—water the rest.