Salvia plebeia and Centella asiatica Extract Composition for Anti-Inflammation

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Solution Overview

Problem

Current anti-inflammatory and antioxidant treatments for inflammatory diseases often come with side effects such as cytotoxicity and decreased antioxidant activity, necessitating the development of safer, more effective natural alternatives.

Innovation Solution

A composition combining Salvia plebeia R. BR. and Centella asiatica extracts, optimized at a 7:3 weight ratio, is used to create a cosmetic and pharmaceutical formulation that enhances antioxidant and anti-inflammatory effects while minimizing cytotoxicity.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If steroidal anti-inflammatory drugs are used to treat inflammatory diseases, then anti-inflammatory effect is improved, but side effects such as cytotoxicity and decreased antioxidant activity occur

Engineering Contradiction:

Improveanti-inflammatory effectVSAvoidside effects and cytotoxicity

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent changes the chemical composition parameters by replacing steroidal compounds with natural plant extracts (Salvia plebeia and Centella asiatica) that have different chemical structures and biological properties, thereby maintaining anti-inflammatory effects while eliminating harmful side effects

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent uses a composite formulation combining two different plant extracts (Salvia plebeia extract and Centella asiatica extract) to achieve synergistic effects, where the combination provides both anti-inflammatory and antioxidant activities that neither component alone can fully deliver

Inventive Principle:

Principle #40Composite materials

2Reliability

If Salvia plebeia R. BR. extract is used alone, then antioxidant effect is improved, but cytotoxicity increases

Engineering Contradiction:

Improveantioxidant effectVSAvoidcytotoxicity

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

Centella asiatica extract acts as an intermediary or moderating agent that reduces the cytotoxic effects of Salvia plebeia extract while preserving or enhancing its antioxidant and anti-inflammatory benefits

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The patent converts the potentially harmful cytotoxic property of Salvia plebeia extract into a beneficial outcome by combining it with Centella asiatica extract, which mitigates the toxicity while maintaining the therapeutic effects

Inventive Principle:

Principle #22Blessing in disguise (Convert harm into benefit)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The composition exhibits excellent radical scavenging abilities, significantly inhibiting inflammation and itch-inducing factors at both gene and protein levels, making it suitable for use in anti-oxidant, anti-inflammatory, and anti-itching applications.

Implementation Method 1

the composition exhibits excellent radical scavenging abilities, significantly inhibiting inflammation and itch-inducing factors

Methodology Applied

Scientific EffectRadical scavenging: Oxidation

Data Source

PatentUS12201663B2Composition for anti-oxidation and anti-inflammation comprising Salvia plebeia R BR extract and Centella asiatica extract

Publication Date: 2025.01.21 ALL IN ON CO LTD

AI summary

The present invention relates to a composition for anti-oxidation and anti-inflammation, comprising a Salvia plebeia R. BR. extract and a Centella asiatica extract as an active ingredient. The composition exhibits a radical scavenging ability, and has excellent antioxidant, anti-inflammatory and anti-itching effects by significantly inhibiting inflammation and itch-inducing factors at gene and protein levels, and thus can be advantageously used as a cosmetic composition for anti-oxidation and anti-inflammation.