Salvia–Paeonia Extract Composition for Lipid Disorder Control
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Solution Overview
Problem
Current treatments for lipid metabolism disorders, such as dyslipidemia, fatty liver, and obesity, often come with side effects like hepatotoxicity, myopathy, skin rashes, and digestive issues, and are not as effective as desired, particularly due to the use of drugs like statins, fibrates, nicotinic acids, Ezetimibe, and Omega-3 fatty acids.
Innovation Solution
A pharmaceutical and health functional food composition utilizing Salvia miltiorrhiza and Paeonia lactiflora extracts, or their mixture, extracted with ethanol, to inhibit preadipocyte differentiation, reduce triglycerides and cholesterol levels, and suppress fatty liver and visceral fat formation, offering a safer and more effective treatment.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If statins are used to treat lipid metabolism disorders, then cholesterol levels are reduced, but hepatotoxicity and myopathy occur
Solution Approach 1:
The patent changes the chemical parameter from synthetic statins to natural compounds (salvia miltiorrhiza and paeonia lactiflora extracts), maintaining the cholesterol-lowering effect while eliminating the harmful side effects through parameter substitution of the active ingredient source
Solution Approach 2:
The patent uses natural plant extracts that can be readily obtained and metabolized by the body, replacing long-acting synthetic drugs with naturally-derived compounds that are processed and eliminated more easily, reducing accumulation and side effects
2Quantity of substance
If fibrates are used to treat lipid metabolism disorders, then triglyceride levels are reduced, but gallstones are caused
Solution Approach 1:
The patent substitutes fibrates with salvia miltiorrhiza and paeonia lactiflora extracts, changing the chemical composition parameter to achieve triglyceride reduction without the gallstone-forming side effect through natural compound action
3Quantity of substance
If nicotinic acids are used to treat lipid metabolism disorders, then cholesterol levels are reduced, but skin flushing and digestive disorders occur
Solution Approach 1:
The patent changes the active ingredient from nicotinic acid to natural plant extracts (salvia miltiorrhiza and paeonia lactiflora), maintaining the lipid-lowering effect while eliminating skin flushing and digestive disorders through natural compound substitution
4Quantity of substance
If Omega-3 fatty acids are used to treat lipid metabolism disorders, then blood lipids are improved, but skin rashes and drug interactions occur
Solution Approach 1:
The patent substitutes Omega-3 fatty acids with salvia miltiorrhiza and paeonia lactiflora extracts, changing the active compound parameter to achieve blood lipid improvement without skin rashes and drug interactions through natural plant-derived compounds
Data Source
AI summary
The present invention relates to a composition comprising a Salvia miltiorrhiza or Paeonia lactiflora extract as an active ingredient for prevention or treatment of lipid metabolism disorder and, more particularly, provides a pharmaceutical composition and a health functional food composition, each comprising a Salvia miltiorrhiza extract, a Paeonia lactiflora extract, or an extract from a mixture of Salvia miltiorrhiza and Paeonia lactiflora as an active ingredient for prevention or treatment of lipid metabolism disorder. The composition prevents the differentiation of preadipocyte cells to adipocyte cells, reduces blood triglyceride and cholesterol levels, and effectively suppresses fatty liver and visceral fat formation and as such, can be advantageously used as a pharmaceutical and food composition for prevention, alleviation, or treatment of lipid metabolism disorder.