SAMe Microcapsules With Protein Wall for Moisture Stability
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Solution Overview
Problem
S-Adenosylmethionine (SAMe) is highly hygroscopic, leading to stability and absorption issues, and existing preparation methods are complex, unsafe, or result in poor dispersibility and low bioavailability.
Innovation Solution
A method for preparing SAMe microcapsules using a core material dispersion and wall material dispersion, comprising SAMe and an acid-resistant filler, with a protein wall material and prebiotic sugar, which are dissolved in water and then heated to prepare an alkaline protein aqueous solution, and a suitable solvent is dissolved in water, and a wall material dispersion prepared by dissolving a protein wall material in water and adjusting the pH to above 10 to obtain an alkaline protein dispersion, followed by heating at 80° C. for at least 10 minutes.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If SAMe is used as a preparation, then it has good therapeutic effects, but it is very easy to absorb moisture leading to poor stability
Solution Approach 1:
The patent embeds SAMe core material inside a protective microcapsule structure with wall material layers. This nesting approach isolates the hygroscopic SAMe from environmental moisture while maintaining its therapeutic properties, effectively resolving the contradiction between stability and hygroscopicity.
Solution Approach 2:
The patent introduces an intermediary wall material (such as proteins, polysaccharides, or polymers) that acts as a barrier between SAMe and moisture. This intermediary layer prevents direct contact with water while allowing the SAMe to remain stable and effective.
2Reliability
If chemical modification of SAMe is used to overcome hygroscopicity, then stability improves, but the process becomes complicated and unsafe
Solution Approach 1:
The patent segments the SAMe preparation into distinct functional components: the active SAMe core and the protective wall material. This segmentation allows independent optimization of each component without complex chemical modifications, simplifying the overall process while maintaining stability.
Solution Approach 2:
The patent employs natural, easily obtainable wall materials (proteins, polysaccharides) that can be prepared through simple physical processes rather than complex chemical modifications. These materials provide adequate protection without requiring sophisticated synthesis procedures.
3Reliability
If silicon dioxide or calcium hydrogen phosphate is used to adsorb active ingredient, then hygroscopicity is reduced, but dispersibility becomes poor and bioavailability is low
Solution Approach 1:
The patent changes the physical and chemical parameters of the wall material to optimize both anti-hygroscopicity and dispersibility. By selecting materials with appropriate molecular structures and adjusting parameters like molecular weight, charge, and hydrophobicity, the patent achieves both moisture protection and good dispersibility in biological systems.
Solution Approach 2:
The patent employs composite wall materials combining multiple components (e.g., proteins with polysaccharides, or polymers with natural additives) that work synergistically to provide both hygroscopic protection and excellent dispersibility. This composite approach overcomes the limitations of single-component adsorbents like silicon dioxide.
4Reliability
If silicon dioxide or calcium hydrogen phosphate is used, then hygroscopicity is reduced, but ignition residue content increases and bioavailability decreases
Solution Approach 1:
The patent employs wall materials that are themselves biocompatible and can be metabolized or excreted by the body without accumulating as residue. The materials serve their protective function and then naturally decompose or are eliminated, avoiding the ignition residue problem associated with inorganic fillers like silicon dioxide.
Solution Approach 2:
The patent uses biodegradable wall materials that can be safely discarded by the body through natural metabolic processes. After fulfilling their protective role, these materials are broken down into harmless substances that the body can process and eliminate, maximizing bioavailability of the SAMe core material.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The prepared SAMe microcapsules exhibit good stability, anti-hygroscopicity, and are friendly to the gastrointestinal tract, with a process that is safe and green, allowing for direct tablet compression without additional excipients.
Implementation Method 1
dissolving a protein wall material in water and adjusting the pH value to above 10 to obtain an alkaline protein dispersion
Implementation Method 2
adding a prebiotic sugar and heating at a temperature of 80° C. to 100° C. for at least 10 minutes
Implementation Method 3
mixing the core material dispersion and the wall material dispersion evenly to obtain a mixed dispersion
Implementation Method 4
granulating and drying the mixed dispersion to obtain microcapsules
Data Source
AI summary
The present invention belongs to the field of food or medicine, and relates to a method for preparing SAMe microcapsules. The SAMe microcapsules prepared by the preparation method of the present invention have good stability and anti-hygroscopicity, and are particularly friendly to the gastrointestinal tract.