Integrated Sample Analysis Device with Sealed Flow Control
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Solution Overview
Problem
Existing sample analysis devices are complex and prone to contamination during the process of transferring biological samples, requiring external devices like pipettes which complicate the operation and increase the risk of sample contamination.
Innovation Solution
A sample analysis device with a liquid storage chamber, optical imaging chamber, and drainage chamber connected through a sealing member that allows for direct flow of the sample reagent from storage to imaging without external devices, using a sealing member that can convert between sealed and non-sealed states to control the flow and a pressure-applying member to enhance flow efficiency.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If external devices like pipettes are used to transfer sample liquid, then the sample can be moved from mixing hole to imaging hole, but the operation process becomes complicated and contamination risk increases
Solution Approach 1:
The patent merges the mixing hole and imaging hole into a single integrated sample chamber with inlet, outlet, and imaging regions. This eliminates the need for external pipetting devices by allowing direct sample flow from inlet through imaging region to outlet, thereby reducing both contamination risk and operational complexity while maintaining sample transfer functionality
Solution Approach 2:
The patent extracts and eliminates the external pipetting device from the sample analysis system. By designing an integrated sample chamber that handles mixing, transfer, and imaging internally, the system removes the contamination-prone external transfer step while preserving the essential sample movement function
2Adaptability or versatility
If multiple chambers and external devices are used, then sample analysis functionality is achieved, but the device structure becomes complex
Solution Approach 1:
The patent combines multiple functional chambers (mixing chamber, imaging chamber, drainage chamber) and their interconnections into an integrated sample analysis device with unified sample flow paths. This merging approach maintains versatile sample analysis functionality while reducing overall device structural complexity through internal integration
Solution Approach 2:
The sample chamber serves multiple functions simultaneously: it acts as both mixing chamber and imaging chamber, incorporates inlet and outlet ports for sample introduction and drainage, and provides internal sample transfer pathways. This multi-functionality eliminates the need for separate external devices, achieving versatility without proportional increases in structural complexity
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Simplifies the operation by eliminating the need for external devices, reduces contamination risk, and enhances flow efficiency through controlled sample transfer and uniform distribution within the optical imaging chamber.
Implementation Method 1
a sealing member that allows for direct flow of the sample reagent from storage to imaging without external devices, using a sealing member that can convert between sealed and non-sealed states to control the flow
Implementation Method 2
a pressure-applying member to enhance flow efficiency
Data Source
AI summary
The embodiments of the present disclosure provide a sample analysis device and a sample analysis system. The sample analysis device includes a base and one or more sample analysis units provided on the base. Each sample analysis unit includes a liquid storage chamber, an optical imaging chamber, a drainage chamber, and a sealing element. The liquid storage chamber is arranged on the base. The optical imaging chamber is arranged on the base, and a side of the optical imaging chamber is connected to the liquid storage chamber. The drainage chamber is arranged on the base. The drainage chamber is connected to the other side of the optical imaging chamber, and the drainage chamber is provided with an opening connecting with atmosphere. The sealing element removably seals the opening.