Sample Analyzer Dynamic Test Mode Selection for Glycated Hemoglobin
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Solution Overview
Problem
Existing sample testing methods, such as glycated hemoglobin tests, often require retesting due to measurement results exceeding effective ranges, leading to reduced efficiency and increased costs.
Innovation Solution
A sample analyzer system that aspirates a blood sample, prepares pretreatment solutions, and selects a test mode based on intermediate measurement information to optimize the preparation of test sample solutions, thereby expanding the effective measurement range and reducing the need for retesting.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If a single test mode is used for glycated hemoglobin testing, then the testing process is simple, but the measurement range is limited and retesting is required when results exceed the effective range
Solution Approach 1:
The system dynamically selects between different test modes (first test mode for high concentration, second test mode for low concentration) based on the measured hematocrit value. This dynamic adaptation allows the system to handle a wide range of glycated hemoglobin concentrations without retesting, resolving the contradiction between measurement range and process simplicity.
Solution Approach 2:
The system changes key parameters (test mode selection) based on the hematocrit measurement. By using hematocrit as a parameter to determine the appropriate test mode, the system expands its effective measurement range while maintaining a relatively simple operational process through automated parameter adjustment.
2Reliability
If multiple test modes are prepared in advance, then the effective measurement range is expanded, but the time and resources required for testing increase
Solution Approach 1:
The system performs a preliminary hematocrit measurement before selecting the appropriate test mode. This preliminary action allows the system to prepare the correct test mode in advance, ensuring accurate testing without requiring multiple simultaneous preparations or retesting, thus maintaining efficiency while improving reliability.
Solution Approach 2:
The system uses feedback from the hematocrit measurement to automatically select the appropriate test mode. This feedback mechanism ensures that the most suitable test mode is chosen based on the sample characteristics, improving testing accuracy while avoiding unnecessary testing steps that would waste time.
3Measurement precision
If retesting is performed when measurement results exceed the effective range, then accurate results are obtained, but testing efficiency is reduced and costs increase
Solution Approach 1:
The system performs a preliminary hematocrit measurement to predict the appropriate test mode before the actual glycated hemoglobin testing. This preliminary action prevents the need for retesting by ensuring the correct test mode is selected from the beginning, thereby maintaining result accuracy while improving testing efficiency and reducing costs.
Data Source
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AI summary
The disclosure relates to a sample analyzer, a sample testing method, and a glycated hemoglobin testing method. The sample analyzer includes: a sample preparation apparatus configured to aspirate a blood sample from a container containing a test blood sample of a subject, and prepare a first pretreatment test solution by using the aspirated blood sample and a pretreatment reagent; a first test apparatus configured to test the first pretreatment test solution to obtain intermediate measurement information of the first pretreatment test solution; a controller configured to select a test mode to be performed from the plurality of different test modes based on the intermediate measurement information, and control the sample preparation apparatus to prepare a test sample solution by using a second pretreatment test solution and a test reagent according to the selected test mode to be performed; and a second test apparatus configured to test the test sample solution to obtain a test result for the test blood sample for a target test item. Sample retesting is thus avoided as much as possible.