Sample Analyzer Mixing Method Using Asymmetric Reagent Injection

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Solution Overview

Problem

Existing blood cell analyzers face challenges in achieving high mixing uniformity between blood samples and reagents, leading to poor reaction effects and inaccurate test results due to inadequate mixing methods.

Innovation Solution

A sample analyzer with a reaction assembly featuring a sampler and a reaction tank where the first reagent forms a swirling flow along the inner wall, misaligned with the sampler, ensuring better mixing by controlling the flow rates and volumes of reagents, and a control unit to manage the fluid discharging actions, enhancing the mixing degree and reaction accuracy.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Ease of operation

If blood sample and reagent are mixed by bubbling after the sampler is immersed in the reagent, then the mixing process is simple, but the mixing degree is insufficient and the reaction effect is poor

Engineering Contradiction:
Improvemixing process simplicityVSAvoidreaction effect accuracy
Core Design Contradiction:
Ease of operationVSMeasurement precision

Solution Approach 1:

The patent applies asymmetry by misaligning the center line of the first through-hole with the sampler position. This asymmetric arrangement causes the reagent to form a swirling flow along the inner wall of the reaction tank rather than flowing directly onto the sampler, thereby improving mixing degree while maintaining operational simplicity

Inventive Principle:
Principle #4Asymmetry

Solution Approach 2:

The patent utilizes hydraulic principles by controlling the reagent to form a swirling flow along the inner wall of the reaction tank. The misaligned through-hole configuration creates a vortex flow pattern that enhances mixing between the reagent and blood sample without requiring complex mechanical mixing devices

Inventive Principle:
Principle #29Pneumatics and hydraulics

2Measurement precision

If the center line of the first through-hole is misaligned with the sampler, then the reagent forms a swirling flow improving mixing, but the structural arrangement becomes more complex

Engineering Contradiction:
Improvemixing degreeVSAvoidthrough-hole arrangement
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The patent implements asymmetry through the misaligned arrangement of the first through-hole center line relative to the sampler. This simple geometric asymmetric design creates the desired swirling flow pattern to improve mixing degree without requiring complex mechanical structures or additional components

Inventive Principle:
Principle #4Asymmetry

3Productivity

If the first reagent flows directly onto the sampler, then the flow path is direct and simple, but the mixing uniformity is poor

Engineering Contradiction:
Improveflow efficiencyVSAvoidmixing uniformity
Core Design Contradiction:
ProductivityVSStability of the object's composition

Solution Approach 1:

The patent applies hydraulic flow control by designing the misaligned through-hole configuration to generate a swirling flow pattern. This swirling flow ensures uniform distribution of the reagent along the inner wall and around the sampler, achieving both efficient flow and uniform mixing without requiring additional flow control mechanisms

Inventive Principle:
Principle #29Pneumatics and hydraulics

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The improved mixing method achieves higher accuracy in test results by ensuring thorough mixing of reagents with biological samples, resulting in more precise analysis and accurate fluid testing.

Implementation Method 1

a first reagent is injected into the reaction tank to form a swirling flow along an inner wall

Methodology Applied
Scientific EffectSwirling flow: Vortex Ring

Data Source

PatentUS20240295577A1Sample analyzer and mixing method
Publication Date: 2024.09.05 SHENZHEN MINDRAY BIO MEDICAL ELECTRONICS CO LTD
  • US20240295577A1 patent drawing
  • US20240295577A1 patent drawing
  • US20240295577A1 patent drawing

AI summary

A sample analyzer, comprising a reaction assembly and a detection assembly, wherein the reaction assembly comprises a sampler and a reaction tank, the sampler is used for collecting a biological sample and injecting the biological sample into the reaction tank, a wall of the reaction tank is provided with a first through-hole used for injecting a first reagent, and a center line of the first through-hole is arranged to be misaligned with the sampler after the sampler moves into the reaction tank, the detection assembly is connected to the reaction tank and is used for drawing fluid from the reaction tank for test. The reaction assembly enables a solution to be more uniformly mixed.