Biological Sample Calibration for Accurate Liquid Height Imaging
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Existing biological sample measurement devices face challenges in maintaining accuracy due to device deviation and lens aberration when measuring samples with multiple component regions, leading to difficulties in downsizing and precise liquid height measurement.
Innovation Solution
A biological sample measurement device that acquires a distortion coefficient and liquid height conversion coefficient from a captured image of a calibrator with a pattern shape, correcting for image distortion and converting pixel measurements to accurate liquid height using a calibration process.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Volume of moving object
If an area camera is used to eliminate scanning mechanisms, then device downsizing is achieved, but measurement accuracy decreases due to lens aberration and device deviation
Solution Approach 1:
The patent applies preliminary action by performing calibration before actual measurement. A calibrator with known pattern dimensions is imaged first to capture lens distortion characteristics and calculate distortion coefficients. These coefficients are stored and applied during subsequent sample measurements to correct for lens aberration and device deviation, thereby maintaining measurement accuracy without requiring scanning mechanisms.
2Measurement precision
If a calibration process is implemented to correct distortion, then measurement accuracy is improved, but device complexity increases
Solution Approach 1:
The patent uses copying by creating a digital model of the optical distortion through calibration. Instead of physically correcting lens aberration, the system captures a distorted image of a calibrator with known dimensions, calculates distortion coefficients that represent the optical imperfections, and applies these coefficients as correction factors. This digital copy of the distortion characteristics allows accurate measurement without adding complex physical correction mechanisms.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The device ensures accurate liquid height measurement by correcting for device deviation and lens aberration, improving analysis precision and enabling device miniaturization.
Implementation Method 1
acquiring a transmission image of near-infrared light transmitted through the biological sample
Data Source
Figure 1
Figure 2A~2B
Figure 3A~3B
AI summary
An object of the present disclosure is to avoid a decrease in liquid height measurement accuracy due to deviation of a measurement device and lens aberration when measuring a biological sample having one or more component regions. A biological sample measurement device according to the present disclosure acquires a distortion coefficient and a liquid height conversion coefficient from a captured image of a calibrator having a pattern shape on a surface thereof, and corrects a liquid height of a sample based on the distortion coefficient and the liquid height conversion coefficient (see Fig. 1).