Biological Sample Cartridge Alignment and Heating Control

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Solution Overview

Problem

Current biological sample analysis is labor-intensive and requires skilled operatives, with many process steps and a need for reliable, localized heating and precise temperature control, which is difficult to automate effectively.

Innovation Solution

A circuit board system that interfaces with a sample cartridge, featuring a resistive heating element and temperature sensor for precise control, along with a method for generating a signal to quickly reach desired temperatures using feedback control, and a high voltage power supply for simultaneous voltage control across multiple components.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Extent of automation

If manual sample analysis is used, then skilled operatives can perform complex processing steps, but the process is labor-intensive and time-consuming

Engineering Contradiction:
Improveautomation of sample processingVSAvoidcomplexity of processing system
Core Design Contradiction:
Extent of automationVSDevice complexity

Solution Approach 1:

The sample processing system is divided into modular cartridges, each containing a specific processing function (e.g., heating, mixing, detection). This segmentation allows complex processing to be broken down into independent, automated modules that can be selectively activated, reducing the complexity of controlling the entire system while maintaining automation capability.

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

The cartridges are designed with integrated control electronics and sensors that enable them to autonomously execute processing steps. The cartridge itself manages its own heating, timing, and data collection without requiring skilled manual intervention, thereby achieving automation while keeping the control system relatively simple.

Inventive Principle:
Principle #25Self-service

2Measurement precision

If localized heating is implemented for specific sample sections, then processing precision is improved, but temperature control difficulty increases

Engineering Contradiction:
Improvetemperature control precisionVSAvoidcomplexity of heating control system
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

Each cartridge section requiring heating is equipped with its own dedicated heating element and temperature sensor, creating a localized control system. This allows precise temperature control for specific regions without requiring complex centralized control, as each local zone operates independently with its own simple thermostat mechanism.

Inventive Principle:
Principle #3Local quality

Solution Approach 2:

Temperature sensors in each cartridge section provide real-time feedback to the control system, which automatically adjusts heating power to maintain the desired temperature. This simple feedback loop enables precise temperature control without complex control algorithms or systems.

Inventive Principle:
Principle #23Feedback

3Extent of automation

If multiple process steps are automated in sequence, then labor requirements are reduced, but processing time increases

Engineering Contradiction:
Improveautomation of processing stepsVSAvoidtotal processing time
Core Design Contradiction:
Extent of automationVSLoss of time

Solution Approach 1:

Multiple processing steps are performed in parallel within the cartridge while the sample is being loaded or during idle system time. For example, heating and mixing operations can be initiated before the sample is fully inserted, so that by the time manual intervention is needed, the automated steps are already complete or nearly complete, thereby reducing total processing time despite automation.

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

The cartridge is designed to maintain continuous processing action without interruption. Multiple heating zones can operate simultaneously, and different processing steps can overlap in time, ensuring that the sample undergoes continuous transformation rather than sequential waiting periods, thus reducing overall processing time while maintaining automation.

Inventive Principle:
Principle #20Continuity of useful action

4Manufacturing precision

If alignment features are added to ensure precise positioning of elements, then positioning accuracy is improved, but device complexity increases

Engineering Contradiction:
Improvepositioning accuracy of elementsVSAvoidcomplexity of alignment system
Core Design Contradiction:
Manufacturing precisionVSDevice complexity

Solution Approach 1:

The alignment features utilize asymmetric geometric shapes and non-standard positioning markers that provide unambiguous orientation information. This allows the cartridge to be correctly positioned only in the proper orientation within the device, achieving high positioning accuracy through simple asymmetric features rather than complex alignment mechanisms.

Inventive Principle:
Principle #4Asymmetry

Solution Approach 2:

The alignment features act as intermediary reference points between the cartridge and device positioning systems. These simple geometric markers or keys provide a straightforward mechanical or optical reference that enables precise alignment without requiring complex active adjustment mechanisms or sophisticated positioning algorithms.

Inventive Principle:
Principle #24Intermediary (Mediator)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Enables reliable, automated sample processing with reduced need for skilled operatives, achieving precise and efficient heating and voltage control, thereby improving the speed and accuracy of biological sample analysis.

Implementation Method 1

A circuit board system that interfaces with a sample cartridge, featuring a resistive heating element and temperature sensor for precise control

Methodology Applied
Scientific EffectResistive heating: Joule Heating

Implementation Method 2

A circuit board system that interfaces with a sample cartridge, featuring a resistive heating element and temperature sensor for precise control

Methodology Applied
Scientific EffectTemperature sensing: Thermistor

Implementation Method 3

The projections may be resiliently mounted. For example they may be spring loaded so that when a sample cartridge is installed in the apparatus a force is applies to the projections to bias them towards the sample cartridge and improve the electrical contact

Methodology Applied
Scientific EffectElasticity: Elasticity

Data Source

PatentUS9176094B2Performance of an analyzer for biological samples
Publication Date: 2015.11.03 WHITESPACE ENTERPRISE CORP
  • US9176094B2 patent drawing
  • US9176094B2 patent drawing
  • US9176094B2 patent drawing

AI summary

An apparatus (11) for processing a sample, circuit board (8008) suited to use in such an apparatus and a method of processing are provided in which the apparatus (11) is provided with alignment features to assist in provided the circuit board and a sample cartridge (9) in the correct position relative to one another. In this way, the plurality of sections for processing a sample in the cartridge (9) are positioned against a plurality of elements, such as a heater (4) for heating the sample cartridge (9) or an electrical contact (EP1-EP4) for powering features on the sample cartridge (9), correctly and can operate independently of one another.