Biological Sample Cooling Validation Using Power Signatures
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Solution Overview
Problem
Current cryopreservation techniques lack effective validation methods to ensure that biological samples are cooled under conditions matching reference standards, which can lead to damage or degradation due to improper cooling protocols, especially for high-value samples like patient-specific cells.
Innovation Solution
Monitoring the cooling operation based on electric power data to compare with reference data, allowing for validation of cooling conditions such as sample volume, composition, and cooling rate, and generating alerts or stopping the process if deviations occur, ensuring that the biological sample is cooled according to established protocols.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If cryopreservation is performed without validation of cooling conditions, then the process is simple and quick, but the biological sample may suffer damage or degradation due to improper cooling protocols
Solution Approach 1:
The patent implements a feedback mechanism where electric power consumption data from the cooling apparatus is continuously monitored and compared against reference data to validate that cooling conditions match the prescribed protocol. This feedback loop ensures sample viability by detecting deviations in real-time without requiring complex direct temperature measurement systems within the sample
Solution Approach 2:
The patent uses electric power consumption as an intermediary parameter to indirectly validate cooling conditions. Instead of directly measuring complex thermal parameters within the sample, the system monitors the power consumed by the cooling apparatus, which serves as a proxy indicator of cooling performance and protocol adherence
2Measurement precision
If electric power monitoring is implemented to validate cooling conditions, then cooling protocol compliance is ensured, but the system complexity and data processing requirements increase
Solution Approach 1:
The patent creates a digital copy or signature of the expected electric power consumption profile for valid cooling protocols. This reference power signature is stored and used for comparison during actual cooling operations, enabling automated validation without complex real-time analysis. The copying approach simplifies data processing by replacing complex thermal modeling with straightforward pattern matching
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This method ensures that biological samples are cooled under validated conditions, reducing damage and maintaining viability, particularly for high-value samples, by providing real-time monitoring and adjustment of cooling protocols.
Implementation Method 1
a cooling apparatus (510) for cooling a sample (105)
Data Source
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AI summary
Disclosed is a computer-implemented method comprising: obtaining first data indicative of electric power supplied to a cooling apparatus during a cooling operation on a biological sample, the cooling operation having a given cooling condition; obtaining second data associated with a reference cooling condition; determining, based on the first data and the second data, whether the given cooling condition has a predetermined relationship with the reference cooling condition; and in response to a determination, by the determining, that the given cooling condition has the predetermined relationship with the reference cooling condition, outputting a control signal. The given cooling condition for the "live" data cooling operation may thus be validated against a reference cooling condition.