Sample Crusher Swing Mechanism for Rapid Hair Analysis

The test process is segmented into two distinct stages: (1) a rapid screening stage using the sample crusher and immunochromatographic method that provides quick results, and (2) a confirmatory stage using LC-MS/MS for definitive accuracy. This segmentation allows most samples to be processed quickly while maintaining high accuracy for confirmatory testing.

The testing process employs periodic action by alternating between rapid screening tests and confirmatory LC-MS/MS tests. The sample crusher enables periodic processing of multiple samples through rapid grinding and extraction, followed by sequential immunochromatographic testing, creating a rhythmic workflow that maximizes throughput while maintaining accuracy.

The testing system is divided into two functional segments: a simple, portable sample crusher with immunochromatographic testing for screening, and a complex LC-MS/MS system reserved only for confirmatory testing. This segmentation reduces the complexity of the primary testing device while maintaining overall test accuracy through the confirmatory stage.

The sample crusher serves as an intermediary device that prepares samples for both rapid screening and confirmatory testing. It acts as a bridge between the simple immunochromatographic method and the complex LC-MS/MS system, enabling the latter to be used only when necessary while maintaining its accuracy advantages.

The sample crusher employs a dynamic swing mechanism where the grinding tube moves in a swinging arc rather than remaining stationary. This dynamic motion enhances grinding efficiency by creating varied impact angles and forces on the sample, while the mechanism itself remains relatively simple, consisting mainly of a pivot point and spring return system.

The swing mechanism introduces mechanical vibration and oscillation to the grinding process. The back-and-forth swinging motion of the grinding tube creates vibrational forces that improve sample disintegration and mixing, enhancing grinding efficiency without requiring complex vibration generators or high-speed rotation mechanisms.

The testing strategy is segmented into a high-sensitivity screening phase using the rapid immunochromatographic method and a high-accuracy confirmatory phase using LC-MS/MS. The rapid test provides high test rates for initial screening, while the confirmatory testing ensures sensitivity and accuracy for positive cases.

The rapid immunochromatographic test serves as an intermediary screening tool that identifies potential positive cases at high speed. It acts as a filter that directs only suspicious samples to the more sensitive but slower LC-MS/MS confirmation, maintaining overall sensitivity while achieving high test rates.