Automated Sample Distribution in Diagnostic Analyzers
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Solution Overview
Problem
Current analytical systems for diagnostics process samples sequentially, limiting throughput and efficiency, as they require sorting and transferring samples from linear to two-dimensional arrangements, which is inefficient and resource-intensive.
Innovation Solution
An automated method and system that loads samples with identifiers, allocates them to a two-dimensional processing plate using pipetting devices with re-usable pipette tips, combines samples with solid support materials, isolates and purifies analytes in a separation station, and washes them using a wash buffer, optimizing sample allocation and reducing consumable usage.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If samples are processed sequentially in a linear arrangement, then the system complexity is reduced, but the processing throughput and productivity are limited
Solution Approach 1:
The patent transitions from processing samples in a one-dimensional linear arrangement to a two-dimensional plate format. This dimensional change allows multiple samples to be processed simultaneously in parallel, significantly increasing throughput while the automated control system manages the increased complexity through software-based sample allocation and tracking
2Reliability
If disposable pipette tips are used for each sample transfer, then contamination is prevented, but consumable costs and waste increase
Solution Approach 1:
The system implements a pipette tip washing and reuse mechanism. After initial use for sample transfer, pipette tips are cleaned through washing cycles that remove residual samples and reagents, allowing the same tips to be reused for subsequent washing operations and potentially future sample processing, thereby reducing consumable waste while maintaining contamination prevention through proper cleaning protocols
Solution Approach 2:
The pipette tips serve multiple functions: initial sample transfer, subsequent washing operations, and potential reuse after cleaning. This multi-functionality reduces the need for disposable tips while maintaining system reliability through proper cleaning and sanitization protocols between uses
3Productivity
If samples are allocated to a two-dimensional processing plate, then processing efficiency and throughput are enhanced, but the complexity of sample allocation and positioning increases
Solution Approach 1:
The automated control system implements feedback mechanisms to track sample positions, monitor processing status, and adjust allocations dynamically. This feedback enables the system to manage the two-dimensional plate configuration efficiently, ensuring correct sample placement and tracking while optimizing throughput and handling any deviations or errors in the processing sequence
Data Source
Figure 1a~1b
Figure 2
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AI summary
A method is described for distributing samples within an automated analyzer from a linear arrangement of sample vessels to a processing plate in a two-dimensional nxm arrangement wherein samples are sorted, followed by transfer with a pipetting device with a linear arrangement to a processing vessel in a two-dimensional nxm arrangement and subsequent processing of samples using a second pipetting device which has a two-dimensional nxm arrangement.