Sample Extraction Chip Segmented Collection for Purity
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Solution Overview
Problem
Current sample extraction chips suffer from low sample purity due to impurities in the sample collection pool, affecting subsequent operations and test results.
Innovation Solution
A sample extraction chip with a modular design featuring a sample-loading lysis unit, liquid release-control unit, extraction unit, liquid switch-control unit, and sample collection unit, where samples flow sequentially through front and rear collection portions, utilizing centrifugal force to separate impurities, thereby improving sample purity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Device complexity
If samples are collected in a single sample collection pool, then the collection process is simple, but the sample purity is low due to impurities mixing
Solution Approach 1:
The sample collection pool is divided into multiple collection chambers (first collection chamber, second collection chamber, third collection chamber) that are spatially separated. Each chamber collects samples at different stages of the extraction process, preventing impurity mixing and improving sample purity while maintaining a relatively simple overall structure.
2Device complexity
If a single collection pool is used, then the device structure is simple, but impurities cannot be effectively separated from samples
Solution Approach 1:
The collection system is segmented into multiple independent chambers that receive samples at different extraction stages. This spatial segmentation prevents harmful impurities from contaminating the final sample, as each chamber is isolated from the others.
Solution Approach 2:
The harmful impurities are extracted and isolated in dedicated chambers (first and second collection chambers) before the purified sample reaches the final collection chamber. This separates the harmful factors from the valuable sample material.
3Productivity
If samples flow directly to collection without intermediate separation, then the extraction process is fast, but sample purity is compromised
Solution Approach 1:
The extraction process is segmented into multiple rapid stages, with each stage collecting in a separate chamber. This allows fast processing without sacrificing purity, as the segmentation enables parallel processing of different extraction phases.
Solution Approach 2:
Impurities are removed in preliminary extraction stages that collect in separate chambers before the final sample collection. This preliminary separation action ensures purity is achieved before the sample reaches the final collection point, maintaining both speed and quality.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The chip achieves segmented sample collection, significantly improving the purity of extracted samples by isolating impurities in the front collection portion, allowing for efficient and precise extraction from the rear collection portion.
Implementation Method 1
the front collection portion and the rear collection portion are sequentially distributed along a rotation direction of the chip body
Data Source
AI summary
A sample extraction chip and a biological reaction device are disclosed according to the present disclosure. The sample extraction chip includes a chip body and a sample extraction module provided on the chip body, the sample extraction module includes a sample-loading lysis unit, a liquid release-control unit, an extraction unit, a liquid switch-control unit, a liquid collection unit and a sample collection unit, which are connected through flow channels in a sequence of extraction. The liquid release-control unit is configured to store and release liquid reagents, and the liquid switch-control unit is configured to switch between communication of the liquid collection unit and the extraction unit and communication of the sample collection unit and the extraction unit. The sample collection unit includes a front collection portion and a rear collection portion which are both in communication with the liquid switch-control unit.