Biological Sample Liquid Transfer Modules for Faster Diagnostics
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Solution Overview
Problem
Conventional tools for diagnosing biological tissues are slow, inefficient, and inaccurate, often requiring multiple procedures and taking over 24 hours to process a sample.
Innovation Solution
A system comprising a primary device with a chamber and reservoirs, a secondary device with mechanical modules for liquid delivery and removal, and a tertiary device for managing liquid transfer between them, allowing for rapid and efficient delivery and removal of liquids to and from a sample.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If conventional diagnostic tools are used, then the processing is thorough, but the processing time exceeds 24 hours and multiple complicated procedures are required
Solution Approach 1:
The system is divided into three distinct devices: a primary device containing the sample and reservoirs, a secondary device with mechanical modules for liquid delivery, and a tertiary device that coordinates operation. This segmentation allows each component to be optimized for its specific function, enabling rapid processing while maintaining diagnostic thoroughness through specialized modular components.
Solution Approach 2:
The primary device is pre-loaded with multiple reservoirs containing different liquids (reagents, stains, buffers) before the diagnostic process begins. This preliminary preparation eliminates the need for manual liquid handling during processing, reducing both time and operational complexity while ensuring all necessary reagents are immediately available for the diagnostic sequence.
2Measurement precision
If multiple complicated procedures are used, then diagnostic accuracy is maintained, but processing time increases significantly
Solution Approach 1:
The system performs liquid delivery, mixing, and removal operations in a continuous automated sequence without interruption. The tertiary device coordinates the secondary device to deliver liquids from reservoirs, mix them with the sample, and remove waste liquids without stopping, maintaining diagnostic accuracy through proper reagent application while reducing total processing time compared to batch-wise manual procedures.
Solution Approach 2:
The primary device contains all necessary reagents and liquids within its reservoirs, making the system self-sufficient. The automated mechanical modules deliver and remove liquids without requiring external intervention or manual handling, ensuring consistent diagnostic accuracy while significantly reducing the time investigators need to spend on sample processing.
3Productivity
If manual liquid handling is used, then flexibility is maintained, but processing efficiency and accuracy decrease
Solution Approach 1:
Manual liquid handling operations are replaced with automated mechanical modules in the secondary device that precisely deliver and remove liquids. These modules use controlled mechanical motion to transfer liquids between reservoirs, the sample chamber, and waste containers, eliminating human error while maintaining the flexibility to perform various diagnostic protocols through programmable control by the tertiary device.
Data Source
AI summary
A system for delivery of liquid to and removal of liquid from a sample is provided. The system includes a primary device that contains the sample and at least one valve configured to allow liquid to be delivered to and removed from the sample; at least one reservoir that is configured to receive a volume of liquid; a secondary device including at least one port configured to receive the at least one reservoir and configured to be coupled to the primary device; and a tertiary device configured to receive the secondary device and comprising mechanical modules that deliver the volume of liquid from the at least one reservoir to the sample and remove the volume of liquid from the sample. Positioning the primary device in the secondary device causes the volume of liquid in the at least one reservoir to be delivered to the sample contained within the primary device.