Sample Preparation Device for Analytical Concentration
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Solution Overview
Problem
Current methods for analyzing biologically active substances, such as blood, bone marrow, and urine samples, are inefficient and costly due to the need for dilution, leading to inaccurate measurements, especially when dealing with small sample quantities and high matrix interference.
Innovation Solution
A method and device that isolate and concentrate substances by 'flushing' them out of their matrix using a minimal amount of liquid, either by washing, dissolving, or extracting, allowing direct delivery to analytical instruments in a highly concentrated form, minimizing matrix interference.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If substances are extracted using known liquids and media as carrier, then substances can be transported to measuring devices, but measurement precision deteriorates due to matrix interference and dilution
Solution Approach 1:
The patent extracts only the essential component (substance to be analyzed) from the sample matrix using a minimal amount of liquid, separating it from interfering matrix components. This selective extraction delivers a concentrated substance solution to the measuring device, improving measurement precision by eliminating matrix interference while maintaining high substance concentration.
Solution Approach 2:
The patent changes the concentration parameter by using a minimal amount of liquid for extraction, thereby concentrating the substance in the extract. This parameter change ensures that the substance is delivered in high concentration to the measuring device, resolving the contradiction between measurement precision and substance concentration.
2Productivity
If samples are diluted for transport to measuring devices, then substances can be transported in solution form, but analysis time increases and measurement accuracy decreases
Solution Approach 1:
The patent performs extraction directly in the sample container using a minimal amount of liquid, eliminating the need for dilution and transfer steps. This direct extraction approach reduces analysis time while delivering concentrated substances to the measuring device, thereby improving both productivity and measurement precision.
Solution Approach 2:
The patent combines the extraction and transport steps into a single operation by delivering the extract directly from the sample container to the measuring device. This merging of steps eliminates intermediate dilution and transfer operations, reducing analysis time while maintaining high substance concentration for accurate measurement.
3Quantity of substance
If small amounts of sample are used, then sample consumption is reduced, but measurement reliability deteriorates due to insufficient substance quantity
Solution Approach 1:
The patent changes the concentration parameter by using a minimal amount of extraction liquid, thereby concentrating the substance in the extract. This parameter change ensures that even small sample amounts yield sufficient concentrated substance for reliable measurement, resolving the contradiction between sample quantity and measurement reliability.
Solution Approach 2:
The patent performs selective extraction of the substance from the sample matrix using a minimal amount of liquid, maximizing the concentration of the substance in the extract. This efficient extraction ensures that sufficient analyte is obtained from small sample amounts, maintaining measurement reliability while minimizing sample consumption.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables precise and reliable analysis of small sample amounts by delivering substances in a highly concentrated state directly to measuring devices, reducing analysis time and improving measurement accuracy.
Implementation Method 1
a) by washing out, dissolving or extracting with a liquid (e.g. a solvent or extractant)
Implementation Method 2
dissolving or extracting with a liquid (e.g. a solvent or extractant)
Data Source
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AI summary
A method and a device for preparing a qualitative and quantitative analysis of samples are described. The device makes it possible to delimit and isolate a certain region of a solid or liquid sample. Liquid, for example a solvent or an extracting agent, is added in the delimited and isolated region. Thereafter, the resulting mixture of the substance and fluid is pressed out of the enclosed region in a plug-shaped manner using a neutral or the same liquid and fed to the measuring instrument in the form of a highly concentrated solution.