Sample Resistivity Verification for Electrolyte Measurement Accuracy
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Solution Overview
Problem
Conventional sample electrolyte measurement systems lack a separate quantitative means for verifying electrolyte results, leading to potential errors due to electrical or chemical interferences, which are not effectively detected by existing methods.
Innovation Solution
A separate measurement of sample resistivity is used to verify electrolyte results by comparing measured resistivity to an expected value, allowing for the identification of suspect samples and potential interferences, thereby providing added confidence in the accuracy of electrolyte measurements.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If conventional ISE measurement systems are used for electrolyte analysis, then electrolyte concentrations can be measured, but the systems lack a separate quantitative means for verification leading to potential errors from electrical or chemical interferences
Solution Approach 1:
The patent introduces sample resistivity measurement as an intermediary verification method. The resistivity measurement serves as a mediator that indirectly verifies the accuracy of electrolyte measurements by detecting electrical interferences or sample issues without directly measuring electrolyte concentrations. This separate quantitative means allows detection of errors in ISE measurements caused by electrical or chemical interferences.
2Reliability
If simple tests for sample presence are performed, then gross positioning errors can be detected, but these techniques do not provide a second quantitative means for verification of calculated electrolyte results
Solution Approach 1:
The patent changes the measurement parameter from simple presence/absence detection to quantitative resistivity measurement. By measuring the electrical resistivity of the sample, the system obtains a quantitative parameter that can verify electrolyte results. This parameter change enables detection of electrical interferences and provides a second quantitative means for verification beyond simple sample presence tests.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach enhances the reliability of electrolyte measurements by detecting errors or interferences in real-time, reducing the likelihood of erroneous results and improving the confidence in the accuracy of clinical analyzer outputs.
Implementation Method 1
One known method for measuring electrolytes is potentiometric measurement of ions using individual sensors employing ionophores to selectively attract the ion of interest. For example, an ion selective electrodes (ISE) measurement of sodium (Na+), potassium (K+), and chloride (Cl-) electrolytes
Implementation Method 2
a separate measurement of a blood serum or plasma sample resistivity for the purpose of verifying the electrolyte results that are being measured at the same time by individual ion selective electrodes
Data Source
AI summary
Verification of patient sample electrolyte results using a separate quantitative measurement of sample resistivity. Sample resistivity may be used to measure small differences in resistivity of one sample to the next, and in comparison to a standard solution, in order to verify the results of sample electrolyte measurements being measured at the same time by, for example, individual ion selective electrodes (ISE) in a clinical analyzer. Providing a separate or secondary quantitative means for verification of the measured results of sample electrolytes using sample resistivity solves the problem of electrolyte result variability in sample electrolyte measurements. The process may compare a measured sample resistivity to an expected resistivity value as a verification of the accuracy of individual electrolyte results. Suspect samples - e.g., where the electrolyte resistivity results do not fit the expected resistivity - may be flagged. This separate verification step provides added confidence in the measured electrolyte results and can identify when problems occur or interferences are present in real time.