SAMe Phytic Acid Complexes for Natural Stability
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Solution Overview
Problem
Current methods for producing stable salts of S-adenosyl-L-methionine (SAMe) methyl donor compounds involve the use of xenobiotic counter-ions, which are costly and not of natural origin, leading to instability and degradation issues.
Innovation Solution
The production of salts or complexes of methyl donors like SAMe with phytic acid or phosphorylated inositol, utilizing natural counter-ions that provide biological activity and stability through a simple and cost-effective process, eliminating the need for xenobiotic substances.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Stability of the object's composition
If xenobiotic counter-ions are used to produce stable salts of SAMe, then stability is improved, but the product becomes costly and loses natural origin
Solution Approach 1:
The patent changes the chemical parameter of the counter-ion from synthetic xenobiotic substances to natural substances (phytic acid and its derivatives). This parameter change maintains stability while eliminating the need for costly synthetic additives, as phytic acid forms stable complexes with SAMe through natural chelation mechanisms.
Solution Approach 2:
The patent achieves homogeneity by using all-natural components (SAMe and phytic acid) that are compatible and naturally occurring. This eliminates the need for multiple different synthetic counter-ions and simplifies the product composition to naturally compatible substances, reducing manufacturing complexity and cost.
2Stability of the object's composition
If xenobiotic counter-ions are used to produce stable salts of SAMe, then stability is improved, but the product is not of natural origin
Solution Approach 1:
The patent extracts and removes xenobiotic counter-ions from the SAMe salt formulation, replacing them with natural phytic acid. This extraction eliminates harmful synthetic components while preserving the essential stabilizing function through natural chelation between phytic acid and SAMe.
Solution Approach 2:
The patent replaces expensive, unstable synthetic counter-ions with a cheap, naturally occurring substance (phytic acid) that provides equivalent or superior stability. Phytic acid is abundant in nature and can be obtained through simple extraction from plant sources, eliminating the need for costly synthetic chemistry.
3Ease of manufacture
If simple and cost-effective process is used with natural counter-ions, then ease of manufacture is improved, but stability may be compromised
Solution Approach 1:
The patent enables the system to be self-stabilizing through the natural chelation properties of phytic acid. The phytic acid-SAMe complex forms spontaneously through natural chemical affinity without requiring complex stabilization mechanisms, expensive additives, or sophisticated manufacturing controls, achieving both simplicity and stability simultaneously.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The resulting compounds exhibit enhanced stability and biological activity, combining the benefits of methyl donors with the antioxidant and chelating properties of phytic acid, without using xenobiotic components, and can be formulated into stable nutraceutical or pharmaceutical products.
Implementation Method 1
The present invention concerns the production of salts or chelates of methyl donors, such as S-adenosyl-L-methionine or SAMe and betaine or trimethylglycine, with phytic acid or with phosphorylated inositol, with the formation of totally natural stable compounds
Implementation Method 2
The resulting compounds exhibit enhanced stability and biological activity, combining the benefits of methyl donors with the antioxidant and chelating properties of phytic acid
Data Source
AI summary
The invention concerns the production of salts or chelates of methyl donors, in particular S-adenosyl-L-methionine or SAMe and betaine or N,N,N-trimethylglycine, with phytic acid or with phosphorylate inositol, possibly partially salified with metal cations, with the formation of stable, totally natural, compounds having a biological activity typical of the starting methyl donors and also combined with, and enhanced by, the biological activity typical of phytic acid or of inositol.The invention also concerns nutraceutical, pharmaceutical, dietary, phytopharmaceutical or veterinary compositions comrising one or more salts or complexes of methyl donors with phytic acid or its derivatives and the method for the synthesis thereof.