Sandwich Sensor Assembly for Low Sample Volume Multi-Analyte Detection

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Solution Overview

Problem

Existing sensing devices require increased sample volumes with the number of analytes detected, which is undesirable for limited or expensive samples, such as in neonatal cases.

Innovation Solution

A sensor assembly with a first and second planar substrate, where the dielectric layer defines a liquid flow path and sensing areas above electrical contacts, allowing for concurrent testing with reduced sample volume by arranging sensors in a sandwich configuration rather than coplanar.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Adaptability or versatility

If sensors are arranged in a coplanar configuration to detect multiple analytes, then the number of detectable analytes increases, but the required sample volume increases

Engineering Contradiction:
Improvenumber of detectable analytesVSAvoidsample volume
Core Design Contradiction:
Adaptability or versatilityVSQuantity of substance

Solution Approach 1:

The patent transitions from a coplanar (2D) sensor arrangement to a three-dimensional stacked configuration where sensing elements are positioned on opposite surfaces of a substrate. This vertical stacking allows multiple analytes to be detected simultaneously while maintaining a compact footprint, thereby reducing the sample volume required compared to coplanar arrangements.

Inventive Principle:
Principle #17Another dimension (Dimensionality change)

Solution Approach 2:

The patent implements a nested structure where multiple sensing elements are embedded within layers of dielectric material and conductive traces. Each sensing element is surrounded by insulating layers and electrical connections, creating a compact nested arrangement that maximizes the number of detectable analytes within a minimal sample volume.

Inventive Principle:
Principle #7Nested doll (Nesting)

2Productivity

If multiple sensors are integrated into a single assembly to enable concurrent testing, then testing efficiency increases, but device complexity increases

Engineering Contradiction:
Improveconcurrent testing capabilityVSAvoidsensor assembly structure
Core Design Contradiction:
ProductivityVSDevice complexity

Solution Approach 1:

The patent combines multiple sensing elements, dielectric layers, and conductive traces into a single integrated sensor assembly. All sensing elements share common structural components including the substrate, dielectric layers, and electrical connections, which reduces overall device complexity compared to separate sensor units while enabling concurrent testing of multiple analytes.

Inventive Principle:
Principle #5Merging (Combining)

Solution Approach 2:

The patent creates a multi-functional sensor assembly where a single device can detect multiple different analytes simultaneously. Each sensing element is designed to respond to specific analytes while sharing common structural and electrical infrastructure, thereby achieving high productivity without proportionally increasing device complexity.

Inventive Principle:
Principle #6Universality (Multi-functionality)

Data Source

PatentUS11850585B2Low sample volume sensing device
Publication Date: 2023.12.26 SIEMENS HEALTHCARE DIAGNOSTICS INC
  • US11850585B2 patent drawing
  • US11850585B2 patent drawing
  • US11850585B2 patent drawing

AI summary

In one aspect, the inventive concepts disclosed herein are directed to a sensor assembly which contains a first planar substrate and a second planar substrate which respectively support opposing sensor arrays and contains an integrated flow path extending between the first and second substrates.