SAO Illumination Apparatus Using Minimal Selective Excitation Patterns
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Solution Overview
Problem
Conventional Synthetic Aperture Optics (SAO) imaging requires a large number of redundant and irrelevant selective excitation patterns, making it impractical for DNA sequencing due to high costs and low throughput, and is mechanically and thermally unstable.
Innovation Solution
Optimizing the number of selective excitation patterns based on the target's physical characteristics and optical imaging system parameters, using a half-ring arrangement of interference pattern generation modules to generate a minimal set of patterns that correspond to k-space sampling points, reducing the number of iterations and phases needed for imaging.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If a large number of selective excitation patterns are used in conventional SAO imaging, then imaging resolution and completeness are improved, but system complexity, cost, and time requirements increase significantly
Solution Approach 1:
The patent extracts and removes redundant excitation patterns from the conventional SAO imaging process. By analyzing the k-space sampling requirements and identifying which excitation patterns provide essential information versus which are redundant, the invention selectively removes unnecessary patterns while maintaining imaging quality. This extraction of essential components reduces the total number of excitation patterns needed.
Solution Approach 2:
The patent applies partial action by using only the necessary number of excitation patterns rather than all possible patterns. Through optimization based on the target's physical characteristics and optical system parameters, the invention determines the minimum sufficient number of patterns needed, avoiding excessive action that would waste resources while ensuring adequate imaging coverage.
2Measurement precision
If conventional SAO imaging uses multiple excitation patterns with different phases, then imaging completeness is improved, but the number of iterations and time required increase
Solution Approach 1:
The patent extracts and eliminates redundant phase iterations from the conventional SAO process. By analyzing which phase variations provide essential information about the target and which are redundant, the invention removes unnecessary iterations while maintaining imaging completeness. This extraction reduces the total number of iterations required.
Solution Approach 2:
The patent optimizes parameters including the number of excitation patterns, their spatial frequencies, and phase variations to achieve imaging completeness with minimal iterations. By carefully selecting and changing these parameters based on target characteristics and optical system properties, the invention reduces the iteration count while maintaining quality.
3Reliability
If conventional SAO imaging uses redundant excitation patterns, then imaging robustness is improved, but cost and throughput are reduced
Solution Approach 1:
The patent extracts and removes redundant excitation patterns that do not contribute essential information. By identifying and eliminating these redundant patterns, the invention reduces the total number of patterns needed while maintaining imaging robustness through the retained essential patterns. This reduction increases throughput.
Solution Approach 2:
The patent applies partial action by using only the necessary number of excitation patterns rather than all possible patterns. Through optimization based on target characteristics and optical system parameters, the invention determines the minimum sufficient number of patterns needed, avoiding excessive action that would waste time and reduce throughput while ensuring adequate imaging coverage for robustness.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach enables SAO to be used in DNA sequencing with increased throughput and reduced costs, allowing for massive parallelization and stable operation by minimizing the number of excitation patterns and stabilizing the hardware.
Implementation Method 1
Selective excitation (or illumination) 104 may be applied to the imaging target 102 by an illumination apparatus (not shown in FIGS. 1A and 1B) that is configured to cause interference 122 of two or more light beams 131, 132 on the imaging target 102
Data Source
AI summary
A synthetic aperture optics (SAO) imaging method minimizes the number of selective excitation patterns used to illuminate the imaging target, based on the objects' physical characteristics corresponding to spatial frequency content from the illuminated target and/or one or more parameters of the optical imaging system used for SAO. With the minimized number of selective excitation patterns, the time required to perform SAO is reduced dramatically, thereby allowing SAO to be used with DNA sequencing applications that require massive parallelization for cost reduction and high throughput. In addition, an SAO apparatus optimized to perform the SAO method is provided. The SAO apparatus includes a plurality of interference pattern generation modules that can be arranged in a half-ring shape.