Scatterer Measurement via Phase-Aligned Light for Vessel-Specific Lipid Analysis
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Solution Overview
Problem
Current noninvasive lipid measurement methods lack specificity for different blood vessels, as they measure all blood vessels indiscriminately, failing to provide detailed insights into lipid metabolism in arteries and capillaries, which is crucial for diagnosing postprandial hyperlipidemia.
Innovation Solution
A scatterer measuring apparatus and method that uses phase-aligned light to detect blood flow rate and scatterer concentration in the body, allowing for the differentiation of lipid metabolism in specific blood vessels by calculating these parameters based on temporal changes in light intensity distribution.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If noninvasive lipid measurement is performed on all blood vessels indiscriminately, then measurement can be done anywhere in the body, but measurement precision and ability to detect specific blood vessel lipid metabolism is poor
Solution Approach 1:
The patent applies local quality by using light of specific wavelengths that selectively penetrate and interact with different types of blood vessels. By choosing wavelengths that are preferentially absorbed or scattered by arterial blood versus venous or capillary blood, the system achieves vessel-type-specific measurement while maintaining noninvasive capability across multiple locations.
Solution Approach 2:
The system changes optical parameters (wavelength, intensity, pulse duration) to differentiate between blood vessel types. By varying these parameters and analyzing the temporal and spectral characteristics of the reflected or transmitted light, the system can identify and measure lipid metabolism specifically in arteries, capillaries, or veins.
2Measurement precision
If blood collection is performed multiple times over 6 to 8 hours to diagnose postprandialhyperlipidemia, then diagnostic accuracy is improved, but loss of time and operational complexity increases
Solution Approach 1:
The patent implements continuous noninvasive monitoring of lipid metabolism parameters in real-time. Instead of discrete blood collections, the system continuously measures optical properties of blood in specific vessels, providing temporally resolved data that captures postprandial lipid changes without requiring repeated patient visits or prolonged restraint.
Solution Approach 2:
The system replaces the mechanical/invasive blood collection process with optical measurement. By using light interaction with blood components (lipoproteins, cholesterol) in living vessels, the system obtains lipid metabolism information noninvasively, eliminating the need for repeated needle punctures and blood sampling while maintaining diagnostic capability.
3Measurement precision
If detailed study of lipid metabolism in specific blood vessels is required, then measurement precision is improved, but device complexity and measurement difficulty increases
Solution Approach 1:
The patent segments the measurement approach by targeting specific blood vessel types (arteries, capillaries, veins) through selective optical excitation and detection. By dividing the complex task of whole-body lipid measurement into vessel-specific components using wavelength differentiation and temporal analysis, the system achieves detailed metabolism studies without requiring a completely complex new apparatus.
Solution Approach 2:
The system uses optical properties (absorption, scattering, fluorescence) of blood components as intermediaries to indirectly measure lipid metabolism in specific vessels. These optical signatures act as mediators that translate internal metabolic states into externally detectable signals, simplifying the measurement process while maintaining precision.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables the detection of scatterer information, specifically in capillaries, providing detailed insights into lipid metabolism and allowing for more accurate diagnosis of postprandial hyperlipidemia, even outside clinical settings.
Implementation Method 1
a light intensity detector that detects a light intensity distribution of light emitted from the living body
Implementation Method 2
detects a light intensity distribution of light emitted from the living body
Data Source
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AI summary
[Problem to be Solved] There is provided an apparatus and a method that allow detection of scatterer information. [Solution] A scatterer measuring apparatus includes an irradiator that radiates phase-aligned light having a predetermined light intensity to a predetermined site of a living body from outside the living body toward an interior of the living body, a light intensity detector that detects the light intensity distribution of light emitted from the living body, and a controller that calculates a blood flow rate based on a temporal change in the light intensity distribution and calculates scatterer concentration in the living body based on the blood flow rate.