Scavenging Particles for Soluble Biomolecule Sequestration
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Solution Overview
Problem
Current anti-cancer therapies that stimulate the immune system to recognize or destroy cancer often lead to serious autoimmune-like symptoms and side effects, and there is a need for more effective approaches that do not disrupt the body's auto-immunity mechanisms, especially for metastatic cancer.
Innovation Solution
Development of compositions that bind and inhibit the biological activity of soluble biomolecules, such as TNF receptor, to sequester them away from their natural ligands, thereby inhibiting their interactions with other proteins and cells, using particles with immobilized agents that selectively target and neutralize these biomolecules.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If immune system stimulation is used to recognize or destroy cancer, then anti-cancer efficacy is improved, but autoimmune-like symptoms and side effects increase
Solution Approach 1:
The patent extracts and removes soluble biomolecules (such as soluble TNF receptors) from the tumor microenvironment using scavenging particles. These particles selectively bind to and remove the soluble forms of biomolecules that mediate tumor survival signals, thereby disabling tumor defenses without stimulating the immune system, thus avoiding autoimmune-like symptoms while maintaining anti-cancer efficacy
Solution Approach 2:
The patent introduces scavenging particles as intermediary agents that mediate the removal of soluble biomolecules. These particles act as intermediaries between the therapeutic agent and the target biomolecules, selectively binding to soluble forms and removing them from the tumor microenvironment, thereby achieving tumor treatment without direct immune system stimulation
2Reliability
If soluble biomolecule scavenging is used to inhibit tumor survival, then anti-cancer efficacy is improved, but selectivity over membrane-bound forms may be compromised
Solution Approach 1:
The patent applies local quality by designing scavenging particles with specific binding properties that are optimized for soluble biomolecules. The particles have surface characteristics and binding mechanisms that are locally tailored to recognize and bind soluble forms of biomolecules (such as soluble TNF receptors) while avoiding binding to membrane-bound forms, thereby achieving high selectivity and precision in the tumor microenvironment
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach effectively inhibits the proliferation and survival of cancer cells, treats aging and metabolic disorders, and neutralizes toxins and viruses, while minimizing autoimmune disturbances by selectively targeting soluble biomolecules without affecting membrane-bound forms.
Implementation Method 1
The inner surfaces of the particle comprise an immobilized TNF agent, which is capable of binding to the sTNF-R target and sequestering (scavenging) it away from its natural ligands
Data Source
AI summary
The disclosure provides, methods for preparing scavenging particles, as well as methods for attaching capture agents to the particles. The disclosure further provides compositions that bind to and inhibit the biological activity of soluble biomolecules, as well as pharmaceutical compositions thereof. The compositions may comprise a plurality of particles that specifically bind a target, such as a soluble biomolecule or a biomolecule on the surface of a pathogen, to inhibit the target (or pathogen) from interacting with other molecules or cells. Also provided herein are a number of applications (e.g., therapeutic applications) in which the compositions are useful.