Screen Exchange Device for Biological Tissue Size Reduction
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Solution Overview
Problem
Existing methods for processing biological tissues, such as adipose tissue, for regenerative treatment and cosmetic purposes often rely on enzyme degradation, which raises safety concerns due to the toxicity of the enzymes used.
Innovation Solution
A screen exchange device with a disk featuring multiple screens, each with through-holes of varying characteristics, is used to minimize coupling and decoupling with a container containing biological tissue, effectively reducing tissue size and separating target materials without enzymes.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of manufacture
If enzyme degradation method is used to process biological tissue, then tissue decomposition is achieved, but toxic enzymes cause safety concerns
Solution Approach 1:
The patent replaces the chemical enzyme degradation system with a mechanical size reduction system using screens and grinding mechanisms. The biological tissue is processed mechanically through screens with specific pore sizes and grinding elements, eliminating the need for toxic enzymes while achieving the same tissue decomposition and size reduction goals.
2Manufacturing precision
If multiple screens with different through-hole characteristics are used, then separation precision of target materials is improved, but device complexity increases
Solution Approach 1:
The patent combines multiple screens with different pore sizes and characteristics into a single integrated screen assembly that can be selectively positioned. The manipulation mechanism integrates screen selection, positioning, and tissue processing functions into one coordinated system, reducing operational complexity while maintaining high separation precision through the use of multiple screen types.
Solution Approach 2:
The screen assembly is designed to be dynamically selectable and reconfigurable during operation. Different screens can be brought into contact with the biological tissue based on the specific separation requirements, allowing the system to adapt its complexity level to the task at hand while maintaining high precision separation capabilities.
3Loss of time
If screen exchange mechanism is minimized, then operation time is reduced, but ability to separate various target materials with different sizes is compromised
Solution Approach 1:
The screen assembly is designed as a universal component that can perform multiple separation functions with different screen configurations. The same basic assembly structure can be used for separating various target materials of different sizes by simply changing which screen is active, eliminating the need for multiple separate processing units and reducing coupling/decoupling time while maintaining versatility.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The device efficiently reduces the size of biological tissues and separates target materials by utilizing screens with different through-hole characteristics, minimizing damage to stem cells and avoiding the use of toxic enzymes.
Implementation Method 1
a disk including a plurality of screens, each having at least one through-hole to reduce a size of a biological tissue
Data Source
AI summary
A method for separating a target material from a biological tissue, the method including: a first centrifugation step of centrifuging a biological tissue at a first centrifugal acceleration to remove a non-target material and obtain a plurality of types of materials comprising a target material; a step of reducing a size of a remaining biological tissue by sequentially selecting a plurality of screens having different through-hole characteristics; a second centrifugation step of centrifuging the plurality of types of materials comprising the remaining biological tissue at a second centrifugal acceleration different from the first centrifugal acceleration; and a first separation step of separating a material layer containing a target material.