Screen Filter Cell Collection via Localized Guiding
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Solution Overview
Problem
Existing cell collecting devices face difficulties in identifying and recovering target cells, such as cancer cells, from filters due to their dispersion over the entire surface, making it hard to determine the filtered state and collect them efficiently.
Innovation Solution
A cell collecting device with a conduit and a screen filter that guides target cells toward a specified region near the tubular wall, using a screen filter with filtering holes and a trap or concave/convex portions to gather cells, allowing for easy collection through an outlet.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If cancer cells are dispersed over the entire surface of the filter, then the filtering coverage is improved, but it becomes difficult to identify and recover the filtered cancer cells
Solution Approach 1:
The screen filter is designed with a specific geometric shape (curvilinear, concave, or convex) that creates a localized collection region rather than dispersing cells uniformly across the entire surface. This concentrates the filtered cancer cells in a specific area, making them easier to identify and recover while maintaining effective filtering coverage throughout the device
Solution Approach 2:
The invention transitions from a flat, two-dimensional filter surface to a three-dimensional structured screen filter with concave or convex portions. This dimensional change creates natural cell accumulation zones where filtered cancer cells are guided and concentrated, solving the recovery difficulty while preserving filtering effectiveness
2Area of stationary object
If cancer cells are dispersed over the entire surface of the filter, then the filtering area is maximized, but the identification of filtered state becomes difficult
Solution Approach 1:
By creating localized collection regions with specific geometric features (concave or convex portions), the filter concentrates visual indicators of successful filtration in discrete areas. This allows operators to quickly identify where cells have been captured without needing to examine the entire filter surface, solving the detection difficulty while maintaining large filtering area
Solution Approach 2:
The geometric shape changes on the screen filter create visual contrast and distinct patterns that indicate cell accumulation. These shape variations serve as visual markers that make it easier to detect and measure the filtered state, allowing quick assessment of filtration effectiveness
3Device complexity
If a traditional flat filter is used, then the device structure is simple, but the collection efficiency of target cells is low
Solution Approach 1:
The screen filter incorporates curvilinear, concave, or convex geometric shapes instead of a flat surface. These curved features passively guide and concentrate target cells into specific collection regions through flow dynamics and cell-deposit interactions, significantly improving collection efficiency while adding only moderate structural complexity that can be manufactured using standard techniques
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This device effectively separates and collects target cells at a specified place, increasing the collection efficiency and making it suitable for analysis, inspection, and clinical tests.
Implementation Method 1
a screen filter installed inside the conduit and configured to guide the target cells toward a specified region
Implementation Method 2
the screen filter including a plurality of filtering holes for filtering the target cells
Data Source
AI summary
A cell collecting device is configured to collect target cells from a fluid sample such as blood or physiological fluid. The cell collecting device includes a conduit through which a fluid sample containing target cells passes. The cell collecting device further includes a screen filter installed inside the conduit and configured to guide the target cells toward a specified region. The screen filter includes a plurality of filtering holes for filtering the target cells.