Water-Soluble Scrub Particles for Stable Peptide Skin Delivery
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Solution Overview
Problem
Existing cosmetic compositions struggle to maintain the stability and biological activity of easily hydrolysable peptides like EGF at room temperature, especially when stored in aqueous conditions, and fail to effectively penetrate these peptides into the skin due to their large molecular weights.
Innovation Solution
A non-aqueous cosmetic composition containing 0.01 wt% to 15 wt% of sharp and hard angulated water-soluble scrub particles with polypeptides, which are dissolved using an aqueous-based cosmetic to penetrate active ingredients into the skin, while maintaining scrubbing effectiveness with additional excipient particles.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If peptides like EGF are stored in aqueous cosmetic compositions, then they can maintain biological activity initially, but they are easily hydrolyzed and lose stability during storage and distribution
Solution Approach 1:
The patent changes the physical state of the peptide from dissolved aqueous form to solid particle form through freeze-drying. This parameter change from liquid to solid state fundamentally alters the chemical environment, preventing water-mediated hydrolysis while maintaining peptide stability and biological activity during storage.
Solution Approach 2:
The patent creates a composite structure by encapsulating the peptide within a matrix of excipients (such as sugars or polymers) during freeze-drying. This composite material approach provides a protective environment that stabilizes the peptide against hydrolysis and other degradation mechanisms while maintaining its biological activity.
2Ease of operation
If peptides are applied topically to skin, then they can potentially treat skin conditions, but their large molecular weight prevents effective penetration into the skin
Solution Approach 1:
The patent uses physical exfoliation particles to segment and remove the stratum corneum barrier, creating pathways for peptide penetration. By mechanically disrupting the skin barrier in a controlled manner, the formulation enables subsequent peptide absorption that would otherwise be blocked by the intact barrier.
Solution Approach 2:
The formulation performs preliminary barrier disruption through the exfoliating particles before peptide delivery. This preliminary action of removing or compromising the stratum corneum barrier creates favorable conditions for subsequent peptide penetration, effectively solving the molecular weight barrier issue.
3Reliability
If conventional stabilization methods like freeze-drying with polysaccharides are used, then peptide stability is improved, but the complexity of the formulation and manufacturing process increases
Solution Approach 1:
The excipient particles serve multiple functions simultaneously: they act as stabilizing matrix during freeze-drying, provide physical exfoliation capability, and serve as carriers for the peptide. This multi-functionality reduces the need for separate stabilization components and simplifies the overall formulation architecture.
Solution Approach 2:
The patent merges the stabilization function with the exfoliation function by using the same excipient particles for both purposes. Instead of separate stabilization agents and exfoliants, the formulation combines these functions into a unified particle system, reducing formulation complexity.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition stabilizes peptide activity during storage and distribution, effectively penetrates peptides into the skin, and improves skin conditions such as wrinkle reduction.
Implementation Method 1
water-soluble scrub particles with polypeptides, which are dissolved using an aqueous-based cosmetic
Data Source
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AI summary
The present invention relates to a non-aqueous cosmetic composition comprising water-soluble scrub particles containing a polypeptide or a cell culture component. More specifically, the present invention relates to a non-aqueous cosmetic composition comprising 0.01 wt% to 15 wt% of hard and angulated water-soluble scrub particles containing cell culture components or various polypeptides including a peptide and an oligopeptide. Further, the cosmetic composition of the present invention provides a non-aqueous cosmetic composition which does not comprise active ingredients, but comprises water-soluble excipient scrub particles for maintaining or improving a scrubbing effect and adjusting viscosity or volume.