SDHI-Dithiocarbamate Fungicide Combinations for Broad Disease Control
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Solution Overview
Problem
There is a need for fungicidal combinations that provide broader disease control spectrum, improved crop greening, delayed senescence, and increased yield, while addressing issues of crop tolerance and resistance to existing fungicides.
Innovation Solution
A fungicidal combination comprising at least one succinate dehydrogenase inhibitor, at least one dithiocarbamate fungicide, and at least one other fungicide, specifically ergosterol biosynthesis inhibitors or Quinone outside inhibitors, which synergistically enhance disease control and crop health.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If SDHI fungicides are used alone, then high potency against specific fungal diseases is achieved, but broad spectrum disease control is limited
Solution Approach 1:
The patent combines SDHI fungicides with dithiocarbamate fungicides and at least one other fungicide from classes such as QoI, ergosterol biosynthesis inhibitors, or mitosis affectors into ternary or higher combinations. This merging of multiple fungicide classes with different modes of action achieves broad spectrum disease control while maintaining high efficacy through synergistic interactions among the components.
2Reliability
If higher doses of fungicides are applied, then disease control efficacy is improved, but crop tolerance decreases and resistance increases
Solution Approach 1:
The patent changes the dosage parameters by applying lower individual doses of each fungicide component in the combination compared to single fungicide applications. The synergistic interaction among SDHI, dithiocarbamate, and other fungicides allows achieving enhanced disease control at reduced dosages, thereby maintaining crop tolerance and delaying resistance development.
Solution Approach 2:
The patent creates a composite fungicidal system combining multiple chemically distinct fungicide classes (SDHI, dithiocarbamate, QoI, etc.) in specific ratios. This composite approach provides broad spectrum activity and synergistic effects that enhance efficacy while allowing lower application rates, reducing the risk of resistance and maintaining crop tolerance.
3Reliability
If existing binary combinations of SDHI and dithiocarbamate are used, then some disease control is achieved, but spectrum and efficacy can be further improved
Solution Approach 1:
The patent segments the disease control function into multiple targeted actions by including SDHI for respiratory inhibition, dithiocarbamate for multi-site contact activity, and additional fungicides from different classes (QoI for electron transport inhibition, ergosterol inhibitors for cell membrane disruption, or mitosis affectors for cell division interference). This segmentation of functional targets achieves comprehensive broad spectrum coverage while maintaining high efficacy against diverse fungal pathogens.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The combination achieves enhanced efficacy in controlling fungal diseases, reduces disease incidence, delays senescence, and increases crop yield by improving photosynthesis and greening.
Implementation Method 1
These molecules specifically bind to the ubiquinone-binding site (Q-site) of the mitochondrial complex II, thereby inhibiting fungal respiration
Implementation Method 2
The combination achieves enhanced efficacy in controlling fungal diseases, reduces disease incidence, delays senescence, and increases crop yield by improving photosynthesis and greening
Data Source
AI summary
A combination including a dithiocarbamate fungicide, a succinate dehydrogenase fungicide and at least one of ergosterol biosynthesis inhibitor fungicide or a quinone outside inhibitor fungicide.