Topical Formulation Using SDS, TCAA and Iron (III) for Pathogen Elimination
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Solution Overview
Problem
Current animal skin and hoof treatments contain toxic or carcinogenic substances, posing health risks and leading to the prohibition of some products, necessitating the development of safer alternatives for treating diseases caused by pathogen micro-organisms.
Innovation Solution
A topical formulation comprising sodium dodecyl sulphate (SDS), 2,2,2-trichloroacetic acid (TCAA), and a stable colloidal suspension of nano-particles of iron (III) that synergistically generates reactive oxygen species to eliminate pathogens without toxicity, promoting oxidative stress and protein precipitation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional compositions containing formalin, antibiotics, or other traditional agents are used to treat animal skin and hoof diseases, then effective pathogen elimination is achieved, but toxic or carcinogenic effects on the animal occur
Solution Approach 1:
The patent changes the chemical parameters by using TCAA at controlled concentrations (5-20%) combined with specific iron salts and hydrogen peroxide, creating a formulation that achieves pathogen elimination through oxidative stress rather than direct toxic action. This parameter change allows effective treatment while reducing animal toxicity
Solution Approach 2:
The patent converts the potentially harmful reactive oxygen species into a beneficial therapeutic agent. By combining TCAA, iron salts, and hydrogen peroxide, the formulation generates controlled oxidative stress that eliminates pathogens while the SDS and other components mitigate harm to the animal's healthy tissues
2Reliability
If strong biocidal agents are used to eliminate pathogens in skin and hoof treatments, then pathogen elimination effectiveness is improved, but the formulation becomes harmful to the animal
Solution Approach 1:
The patent introduces SDS (sodium dodecyl sulfate) as an intermediary substance that mediates between the biocidal action and the animal's tissues. SDS acts as a surfactant that enhances penetration of the active ingredients to the pathogen sites while also protecting healthy tissues from direct contact with the harsh oxidizing agents
Solution Approach 2:
The formulation uses a composite approach by combining multiple substances (TCAA, iron salts, hydrogen peroxide, SDS, and optional plant extracts) that work synergistically. Each component contributes a specific function: TCAA and iron salts generate oxidative stress, hydrogen peroxide provides additional oxidizing power, SDS enhances delivery and protection, and plant extracts add soothing properties
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The formulation effectively treats skin and hoof diseases in animals by exerting localized cytotoxic action against pathogens, offering a non-toxic, odorless, and stain-free solution that repairs lesions and eliminates micro-organisms without harming the animal.
Implementation Method 1
SDS exerts a perturbing action on the cell membranes of bacteria, and denatures the proteins weakening intramolecular interactions. In addition, also being a detergent, SDS allows the dispersion in aqueous media of hydrophobic compounds insoluble in water, including the proteins of the cell membranes, which are thus extracted and solubilised.
Implementation Method 2
Various studies have suggested that the acidic nature of TCAA is important for the induction of conformational changes that trigger the precipitation of the proteins. Further studies have also suggested that TCAA acts as a sequestrant of the water bound to the proteins, thus forcing the latter to come out of the solution and precipitate.
Implementation Method 3
a stable colloidal suspension of (nano-)particles of iron (III), advantageously as a catalyst to generate in water, and in vivo, cytotoxic substances known as reactive oxygen species
Implementation Method 4
In other words, component iii) preferably acts as a pro-oxidant, capable of inducing oxidative stress through the creation of reactive oxygen species, such stress being suitable to cause damage to cells or tissues of pathogenic micro-organisms.
Data Source
AI summary
This invention relates to a formulation for use in the. topical treatment of diseases caused by pathogen micro- organisms and/or parasites in animals, comprising sodium dodecyl sulphate, 2, 2, 2-trichloroacetic acid and a stable colloidal suspension of (nano-) particles, of iron (III). The invention further relates to a process for the manufacture of a formulation, and uses of the same formulation and its components.