Sealed Reagent Temperature Control via Dual-Sensor Feedback

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Solution Overview

Problem

Existing sample analysis techniques face challenges in maintaining uniform reaction temperatures for sealed reagents, leading to inaccurate results due to ambient temperature variations and reagent evaporation, which increases costs and complicates apparatus design.

Innovation Solution

A method involving temperature measurement of both the container and ambient environment to determine and control the heat energy supplied to the container, ensuring the reagents reach a predetermined temperature without exposure, using a heat medium like a heating block and a controller to regulate heat energy based on pre-calculated correlations.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If reagents are exposed to air for temperature measurement, then temperature control is achieved, but reagent evaporation occurs and apparatus structure becomes complicated

Engineering Contradiction:
Improvetemperature measurementVSAvoidreagent evaporation
Core Design Contradiction:
Measurement precisionVSLoss of substance

Solution Approach 1:

The patent uses the container as an intermediary object to measure temperature indirectly. Instead of measuring reagent temperature directly (which requires exposure), the system measures container temperature and uses it to infer reagent temperature, eliminating the need for air exposure while maintaining temperature control capability

Inventive Principle:
Principle #24Intermediary (Mediator)

Solution Approach 2:

The system creates a thermal model that copies the relationship between container and reagent temperature. By measuring container temperature and applying pre-determined correlation data, the system obtains reagent temperature information without direct contact or exposure

Inventive Principle:
Principle #26Copying

2Loss of substance

If reagents are sealed in a container, then evaporation is prevented, but direct temperature measurement becomes difficult

Engineering Contradiction:
Improvereagent evaporation preventionVSAvoidtemperature measurement mechanism
Core Design Contradiction:
Loss of substanceVSDevice complexity

Solution Approach 1:

The container serves as a thermal intermediary that transmits temperature information from the sealed reagents to external sensors. The system measures container temperature and uses correlation data to determine reagent temperature, maintaining seals while enabling measurement

Inventive Principle:
Principle #24Intermediary (Mediator)

Solution Approach 2:

The patent replaces complex mechanical temperature measurement mechanisms (that would require opening seals) with a thermal modeling approach. By measuring container temperature and applying mathematical correlations, the system obtains reagent temperature without mechanical intervention in the sealed system

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

3Temperature

If heat energy is constantly supplied to the container, then reagent temperature is raised, but reaction temperature varies with ambient temperature changes

Engineering Contradiction:
Improvereagent temperatureVSAvoidreaction temperature uniformity
Core Design Contradiction:
TemperatureVSReliability

Solution Approach 1:

The system implements feedback control by continuously measuring container temperature, comparing it with the target reagent temperature, and adjusting heat supply accordingly. The control unit modifies heating power based on real-time temperature differences, maintaining consistent reaction temperatures despite ambient variations

Inventive Principle:
Principle #23Feedback

Solution Approach 2:

The patent applies preliminary action by using pre-determined correlation data between container and reagent temperatures. This correlation information is established in advance to account for thermal relationships, allowing the system to predict and compensate for temperature variations before they affect reaction uniformity

Inventive Principle:
Principle #10Preliminary action

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This approach allows for precise temperature control of sealed reagents, preventing evaporation and ensuring uniform reaction temperatures, thereby enhancing analysis accuracy and reducing costs by minimizing reagent usage.

Implementation Method 1

a heating block brought into contact with the container for supplying heat energy to the container

Methodology Applied
Scientific EffectHeat conduction: Conduction (thermal)

Implementation Method 2

a temperature measuring device for measuring the ambient temperature around the container

Methodology Applied
Scientific EffectTemperature measurement:

Data Source

PatentUS8696993B2Method of raising temperature of received object, and analyzing device
Publication Date: 2014.04.15 ARKRAY INC
  • US8696993B2 patent drawing
  • US8696993B2 patent drawing
  • US8696993B2 patent drawing

AI summary

The present invention relates to an analyzing apparatus (1) for analyzing a sample using a container (2) accommodating reagents sealed therein, while raising the temperature of the reagents up to a predetermined temperature. The analyzing apparatus (1) comprises a first temperature measuring means (31) for measuring temperature of the container (2), a second temperature measuring means (32) for measuring temperature around the container (2), a heater (4) for supplying heat energy to the container (2), and a controller for controlling the heater (4) based on a measurement result at the first and second measuring means (31, 32).