Sealing Catheter Isolates Vessel for Localized Aneurysm Treatment
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Solution Overview
Problem
Current treatments for aneurysms are invasive and carry significant risks, including surgical complications and the potential for aneurysm progression after surgery, with limited options for deep-seated aneurysms and incomplete solutions due to vascular graft loosening.
Innovation Solution
A medical device comprising a sealing catheter and introducer sheath with extendable elements that can isolate a section of a blood vessel, allowing for the aspiration of blood and localized delivery of therapeutic compositions to reduce aneurysm pressure and stabilize vessel walls, using balloons that can be inflated and deflated to adjust the isolated volume.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If invasive surgical techniques such as endovascular stent graft repair or vascular graft replacement are used to treat aneurysms, then life-saving treatment and improved quality of life are achieved, but surgical complications, device-related complications, and risk of aneurysm progression after surgery occur
Solution Approach 1:
The treatment approach segments the vascular system by isolating the aneurysm within a defined treatment zone using sealing balloons, separating it from the systemic circulation. This allows localized treatment of the aneurysm without subjecting the entire vascular system to invasive surgical intervention or systemic exposure to therapeutic agents.
Solution Approach 2:
The invention applies local quality by delivering therapeutic compositions directly to the isolated aneurysm site within the sealed zone, concentrating the treatment effect where needed while minimizing systemic exposure. The sealing balloons create a localized environment where therapeutic agents can act directly on the aneurysm wall without dilution or distribution throughout the body.
2Strength
If vascular grafts are used to replace diseased vessels, then immediate structural support and aneurysm exclusion are achieved, but graft loosening and dislodgement can occur if the aneurysm progresses
Solution Approach 1:
The invention applies preliminary action by isolating the aneurysm with sealing balloons and aspirating blood from the isolated volume before delivering therapeutic compositions. This preparatory treatment stabilizes the aneurysm wall and reduces pressure, preventing future progression that could lead to graft complications.
Solution Approach 2:
The treatment approach enables the vessel to heal itself by delivering therapeutic compositions that promote natural repair mechanisms. The stabilized aneurysm wall can undergo biological healing processes without requiring permanent mechanical support from grafts, allowing the native vessel to maintain long-term stability.
3Quantity of substance
If therapeutic compositions are delivered systemically to treat aneurysms, then widespread distribution of treatment agents is achieved, but dilution of the composition and reduced treatment efficacy occur
Solution Approach 1:
The sealing balloons create a localized treatment zone where therapeutic compositions can be delivered with high concentration directly to the aneurysm site. This localized delivery prevents dilution that would occur with systemic administration, ensuring maximum treatment efficacy at the target site while minimizing the total quantity of therapeutic agent required.
4Adaptability or versatility
If adjustable isolated volume is created using sealing balloons, then flexible treatment zone definition and blood aspiration capability are achieved, but increased device complexity is introduced
Solution Approach 1:
The sealing balloon device integrates multiple functions into a single system: it provides vessel sealing, creates an isolated treatment zone, enables blood aspiration, and allows delivery of therapeutic compositions. This multi-functionality reduces the need for multiple separate devices while maintaining high adaptability for different treatment scenarios.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The device enables less invasive treatment of aneurysms by reducing aneurysm volume and stabilizing vessel walls, minimizing systemic exposure of therapeutic agents, and providing a versatile solution for various vascular conditions, with the potential for repeated treatments and improved patient safety.
Implementation Method 1
The extendable element can comprise a flexible, fluid impermeable membrane that has in the extended configuration a distal end, a proximal end and a generally cylindrical surface between the distal end and the proximal end. The extendable element can comprise a balloon.
Implementation Method 2
Before the delivery of the treatment composition, the blood in the isolated volume including the aneurysm or a portion thereof can be aspirated to reduce the pressure on the aneurysmal wall
Data Source
AI summary
Devices for the isolation of a selected portion of a vessel are described. In some embodiments, the device has an introducer sheath and a sealing catheter that are movable relative to each other to create an isolated volume with adjustable size and location. The methods for the treatment of vascular aneurysms using the devices are described. The treatment is achieved through the delivery of an effective amount of stabilization agent to an isolated volume that encompass the aneurysm. The device optionally has an aspiration device to improve the effectives of the treatment.