Seamless Extracellular Matrix Valve for Perivalvular Leakage

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Solution Overview

Problem

Conventional prosthetic valves often suffer from perivalvular leakage due to seams in tubular constructs, requiring skilled surgical techniques for secure attachment to cardiovascular vessels, and can induce intimal hyperplasia and harsh biological responses.

Innovation Solution

Development of seamless extracellular matrix (ECM) prosthetic valves with a triple-walled intermediate portion and internal valve leaflets, formed by everting and reverting tubular members, and optionally incorporating biologically active agents or pharmacological agents, along with anchoring mechanisms for secure positioning.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Ease of manufacture

If conventional prosthetic valves are constructed with seams in tubular structures, then the valve can be manufactured using traditional techniques, but perivalvular leakage occurs

Engineering Contradiction:

ImprovemanufacturabilityVSAvoidperivalvular leakage

Core Design Contradiction:

Ease of manufactureVSReliability

Solution Approach 1:

The tubular structure is divided into multiple layers (first layer, second layer, third layer) that are joined together to form a seamless construction, eliminating the harmful seam while maintaining manufacturability through layered assembly

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

The valve leaflet is nested within the tubular structure, with the tubular structure formed by joining layers together to create a seamless outer structure that contains the leaflet, eliminating external seams

Inventive Principle:

Principle #7Nested doll (Nesting)

2Reliability

If skilled surgical techniques are used for secure attachment, then reliable attachment to cardiovascular vessels is achieved, but the surgical process becomes complex and time-consuming

Engineering Contradiction:

Improveattachment reliabilityVSAvoidsurgical complexity

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The tubular structure is pre-formed with a seamless construction and integrated leaflet configuration before implantation, eliminating the need for complex intraoperative assembly and attachment procedures while ensuring reliable attachment

Inventive Principle:

Principle #10Preliminary action

3Productivity

If conventional prosthetic valves are implanted, then valve replacement is achieved, but intimalhyperplasia and harsh biological responses are induced

Engineering Contradiction:

Improvevalve replacement effectivenessVSAvoidintimalhyperplasia

Core Design Contradiction:

ProductivityVSObject-affected harmful factors

Solution Approach 1:

The material composition and structural parameters of the tubular structure are changed to create a biocompatible seamless construction that reduces immune response and prevents intimalhyperplasia while maintaining valve functionality

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The valve is constructed using composite material layers that combine biocompatibility with structural integrity, reducing harsh biological responses while maintaining effective valve replacement

Inventive Principle:

Principle #40Composite materials

Data Source

PatentUS9011526B2Tubular extracellular matrix prosthetic valve

Publication Date: 2015.04.21 CORVIVO CARDIOVASCULAR INC

AI summary

A seamless prosthetic valve having an outer abluminal surface, a triple walled intermediate portion, and at least one valve leaflet that is configured to selectively restrict fluid flow through the valve, the valve leaflet being formed by suturing the triple walled intermediate portion at a first commissure connection point.