Seed Coating Agent Combining Silthiopham and Coumoxystrobin
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Solution Overview
Problem
Current fungicides, such as silthiopham and coumoxystrobin, face challenges in effectively preventing and controlling wheat rot disease due to the development of drug resistance and high application costs, especially since wheat rot disease is soil-borne and has a long incubation period, making early detection difficult.
Innovation Solution
A seed coating composition combining silthiopham and coumoxystrobin with salicylic acid and compound sodium nitrophenolate is developed, formulated into a suspension seed coating agent with specific weight percentages, enhancing seed germination and disease resistance while delaying resistance development.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If single fungicides (silthiopham or coumoxystrobin) are used for wheat rot disease control, then initial disease suppression is achieved, but drug resistance develops rapidly reducing long-term effectiveness
Solution Approach 1:
The patent combines silthiopham and coumoxystrobin into a composite fungicide formulation, merging two different chemical mechanisms of action to simultaneously suppress wheat rot disease while preventing resistance development through multi-target inhibition
Solution Approach 2:
The invention uses composite material principles by formulating a mixture of silthiopham (an energy inhibitor) and coumoxystrobin (a strobilurin fungicide), creating a composite fungicide that leverages the complementary properties of both active ingredients to achieve sustained disease control
2Reliability
If chemical pesticides are applied for wheat rot disease prevention, then disease control is achieved, but application cost increases due to frequent applications
Solution Approach 1:
By combining silthiopham and coumoxystrobin into a single composite formulation, the patent reduces the number of separate applications needed while maintaining or improving disease control effectiveness, thereby reducing overall application costs
3Reliability
If seed coating agents are used for early prevention, then disease control effectiveness is maximized, but resistance development accelerates with repeated use
Solution Approach 1:
The composite fungicide formulation containing silthiopham and coumoxystrobin provides prolonged resistance-free service period by targeting multiple physiological pathways in the pathogen, making it harder for the pathogen to develop resistance through single-mutation mechanisms
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition effectively inhibits wheat rot disease, improves seed germination rates, reduces application costs, and extends the efficacy of fungicides, providing economic, high-efficiency, and environmental protection by using different mechanisms of action to prevent resistance.
Implementation Method 1
Silthiopham, the chemical name N-allyl-4,5-dimethyl-2-(trimethylsilyl) thiophene-3-carboxamide, is an energy inhibitor by research, possibly ATP Inhibitor. It can directly inhibit the growth and reproduction of the take-all disease bacteria, interfere with the synthesis of pathogenic bacteria.
Implementation Method 2
Coumoxystrobin, chemical name: (E)-2-(2-(3-n-butyl-4methyl-coumarin-7-yloxy) methylphenyl)-3-methoxy Methyl acrylate, is a strobilurin fungicide. It acts on the fungal mitochondrial electron transport chain complex III to prevent electron transport and inhibit the internal energy synthesis of the fungus
Implementation Method 3
Salicylic acid and compound sodium nitrophenolate can play a role in different aspects to affect the germination of seeds and improve the resistance of seeds. Therefore, seed treatment through hormone adjustment can achieve a certain effect
Data Source
AI summary
A seed coating agent for preventing and treating a wheat rot disease is provided. The seed coating agent includes a fungicide and a seed priming and elicitor. The fungicide includes silthiopham and coumoxystrobin. The seed priming and elicitor includes salicylic acid and compound sodium nitrophenolate. The weight percentage of each components is 1%-60% of the fungicide, 0.0005%-0.05% of salicylic acid, and 0.001%-0.1% of compound sodium nitrophenolate. The seed coating agent has a good effect of promoting seed germination and strengthening seedlings on wheat seeds. Both silthiopham and coumoxystrobin are of low toxicity, and are safe for humans, animals, beneficial organisms, and the environment. It can delay the pathogens resistance to a single agent