Segmented Clot Retrieval Device for Stroke Reperfusion
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Solution Overview
Problem
Current clot removal devices for ischemic stroke treatment face challenges in achieving high revascularization rates due to issues with radial force, vessel trauma, and incomplete reperfusion, leading to suboptimal patient outcomes.
Innovation Solution
A clot retrieval device with a framework of struts forming a porous outer body radially surrounding a porous inner body, capable of being delivered in a collapsed configuration and expanding to define a clot reception space, is used to pass through or about the clot and achieve high revascularization rates by restoring perfusion.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If stent-like clot retriever devices are used to remove clots from cerebral vessels, then clot removal capability is improved, but vessel trauma and perforation risk increase due to excessive radial force
Solution Approach 1:
The device is divided into multiple segments or sections along its length, with each segment capable of independent radial expansion. This segmentation allows the device to apply radial force in a distributed manner rather than concentrated at single points, reducing peak stress on the vessel wall while maintaining effective clot engagement. The segmented structure enables progressive engagement and retrieval without requiring excessive overall radial force.
Solution Approach 2:
Different sections of the device have different radial force characteristics - proximal sections may have higher radial force for secure clot engagement, while distal sections have lower radial force to protect the fragile distal vessel wall. The device incorporates varying strut thicknesses, materials, or expansion forces at different locations to optimize the balance between clot retrieval effectiveness and vessel wall protection throughout the delivery and retrieval process.
2Device complexity
If first generation thrombectomy devices are used, then device simplicity is maintained, but revascularization rates are suboptimal compared to newer stentriever technology
Solution Approach 1:
The device transitions from a static, simple structure to a dynamic structure that can change configuration. The device is delivered in a compressed, low-profile state through the catheter, then dynamically expands to a larger radial profile at the clot site for effective engagement. This dynamic transformation allows the device to achieve high revascularization rates through improved clot capture and retrieval mechanics while maintaining delivery simplicity through the compressed state.
Solution Approach 2:
The device employs a nested configuration where the retrieval structure is contained within or alongside the delivery catheter system. The stent-like structure with its struts and cells is compressed within the delivery system, allowing it to be delivered through standard neurovascular access routes. Upon deployment, the nested structure expands outward to engage the clot, combining the simplicity of catheter-based delivery with the effectiveness of a structured retrieval device.
3Force
If excessive radial force is applied by the device, then clot grip is improved, but device withdrawal force requirement increases and vessel damage occurs
Solution Approach 1:
The device's radial force application is segmented into multiple zones along its length. Proximal segments provide strong radial force for secure clot engagement, while distal segments provide reduced radial force to protect the vessel wall during navigation and retrieval. This segmented force distribution allows the device to maintain adequate clot grip without requiring excessive overall radial force that would damage the vessel.
Solution Approach 2:
The device incorporates variable radial force parameters along its structure, with different strut configurations, materials, or expansion mechanisms at different locations. This allows the device to optimize the radial force profile - applying higher force where needed for clot engagement and lower force where vessel protection is critical - thereby achieving effective clot grip while minimizing vessel wall stress and reducing withdrawal force requirements.
Data Source
AI summary
Method for using a clot retrieval device for treating a clot in a blood vessel for use in the treatment of ischemic stroke to reperfuse an obstructed vessel.