Segmented Detection Device for In Vivo Sample Enrichment
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Solution Overview
Problem
Conventional methods for enriching sample materials, such as circulating tumor cells, from body fluids are inefficient and can damage cells, while in vivo detection devices face challenges like thrombosis due to their design, limiting their ability to diagnose diseases with precision and efficiency.
Innovation Solution
A detection device featuring a guide element with detachable functional elements, each with a surface charged with detection receptors, allowing for independent diagnostic methods and reducing thrombosis risk through a three-dimensional structure that minimizes friction and maximizes sample liquid interaction.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Loss of energy
If a cylindrical detection device is used for in vivo enrichment, then frictional resistance is reduced, but thrombosis risk increases due to blood stream constriction
Solution Approach 1:
The detection device is divided into multiple functional sections arranged in a radial pattern around the guide element, creating a segmented structure that reduces blood stream constriction while maintaining low frictional resistance through the cylindrical outer shape
Solution Approach 2:
The functional sections are arranged in a radial dimension around the guide element, creating a three-dimensional structure that allows blood to flow through the central channel while functional surfaces are exposed to the blood stream, reducing thrombosis risk without increasing friction
2Adaptability or versatility
If multiple detection receptors are used for diagnosing different diseases, then diagnostic versatility is improved, but device complexity increases
Solution Approach 1:
The device is segmented into multiple functional sections, each charged with different detection receptors for different diseases. This segmentation allows each section to be independently optimized for specific diagnostic purposes while maintaining a unified overall structure
Solution Approach 2:
The detection device is designed as a universal platform that can detect multiple different diseases simultaneously through its functional sections equipped with various detection receptors, allowing one device to perform multiple diagnostic functions
3Quantity of substance
If conventional enrichment methods are used, then sample material can be enriched, but cell damage occurs and diagnostic precision is reduced
Solution Approach 1:
Different functional sections are charged with different detection receptors tailored to specific target molecules and cells, allowing localized enrichment of specific analytes while preserving cell integrity through gentle, targeted binding rather than harsh conventional enrichment methods
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables more precise and efficient diagnosis of different diseases by allowing individual functional elements to be subjected to various diagnostic methods, reducing efforts and minimizing sample volume requirements, while preventing thrombosis and protecting ligands from abrasion.
Implementation Method 1
a functional surface charged with detection receptors... which are suited for capturing target molecules and target cells
Data Source
AI summary
The invention relates to a detection device for the in vivo and/or in vitro enrichment of sample material, comprising a functional surface charged with detection receptors. To ensure the diagnosis of different diseases using a detection device of the type mentioned at the outset with less efforts and an improved precision of the diagnosis, it is provided according to the invention that the detection device comprises at least one guide element and at least two functional elements disposed at the guide element, wherein a functional surface charged with detection receptors is formed at each of them, the functional elements being designed for being detachable from each other and/or individually detachable from the guide element. Furthermore, the invention provides a use of and a method for the application of said detection device.