Segmented Peptide for Stable Apatite Binding and Bone Regeneration
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Solution Overview
Problem
Current bone graft materials coated with apatite mineral lack stability, leading to the degradation of biologically active substances like proteins, which hinders prolonged bone regeneration effects due to instability and exposure to systemic blood.
Innovation Solution
A peptide with both bone-forming and apatite-binding capacities is developed by linking specific amino acid sequences, allowing stable immobilization on apatite surfaces, thereby enhancing bone tissue regeneration and maintaining activity over time.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If biologically active substances like proteins are used together with apatite to promote bone regeneration, then bone induction capacity is improved, but stability and prolonged activity on the apatite surface deteriorate due to degradation and exposure to systemic blood
Solution Approach 1:
The invention segments the biologically active substance into a peptide form, which is a smaller, more stable fragment of the original protein. This segmentation allows the peptide to maintain bone-inducing activity while being more resistant to degradation and better suited for stable immobilization on apatite surfaces, thus resolving the contradiction between biological activity and stability.
Solution Approach 2:
The invention changes the molecular parameters of the biologically active substance by converting full-length proteins into shorter peptides with specific amino acid sequences. This parameter change (reducing molecular size and complexity) enhances stability on apatite surfaces while preserving the essential bone-inducing function, thereby resolving the contradiction between reliability and stability.
2Reliability
If proteins are used to provide bone induction capacity, then initial bone morphogenesis is improved, but duration of action deteriorates due to rapid degradation and release into systemic blood
Solution Approach 1:
By segmenting the protein into a smaller peptide fragment, the invention achieves both rapid initial activity for bone morphogenesis and extended duration of action. The peptide's smaller size allows for stable immobilization on apatite, preventing rapid release into systemic blood while maintaining biological activity at the implant site, thus resolving the contradiction between bone induction capacity and duration of action.
Solution Approach 2:
The invention uses a peptide that is inherently more stable and resistant to degradation than full-length proteins. This peptide acts as a durable, long-lasting agent on the apatite surface, effectively extending the duration of action without requiring repeated applications, thereby resolving the contradiction between initial bone induction and prolonged activity.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The peptide effectively promotes cell transition, proliferation, and differentiation, maximizing bone regeneration by remaining stably bound to apatite surfaces, thus enhancing therapeutic outcomes in bone tissue repair.
Implementation Method 1
a peptide having bone tissue regeneration capacity and specifically binding to a surface of apatite mineral
Implementation Method 2
can promote transition, proliferation, and differentiation of cells associated with regeneration and eventually maximize bone tissue regeneration capacity
Data Source
Figure 1~2
Figure 3(a)~3(c)
AI summary
The present invention relates to a peptide having bone tissue regeneration capacity and binding to surface of apatite, and more particularly, to a peptide having bone tissue regeneration capacity and specifically binding to a surface of apatite mineral, capable of being stably immobilized to the surface of apatite mineral to retain effective activity and exhibit bone regeneration effects for a long time, by linking an amino acid sequence having bone tissue regeneration capacity and an amino acid sequence having apatite-binding capacity to each other to thereby provide a peptide having both bone-forming effects and binding capacity to the surface of apatite mineral, and a composition for bone tissue regeneration, containing the peptide. The peptide having binding capacity to the apatite mineral and bone tissue regeneration capacity according to the present invention binds to the surface of apatite to thereby be present in a stable state, and thus can be used in a bone replacement material for dental or orthopedic application, and metal, natural polymers, or synthetic polymers, coated with apatite; promote transition, proliferation, and differentiation of cells associated with regeneration and eventually maximize bone tissue regeneration; and can be stably present while maintaining peptide activity when being grafted into the body and thus is useful in development of the bone tissue regeneration therapeutic technology using the peptide.