Segmented Sample Processing Tubule with Non-Piercing Extraction Port
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Conventional sample preparation methods for diagnostic assays are hindered by the need for complex and costly instrumentation, delayed results, compromised sample integrity, and impracticality due to the requirement for samples to be processed in distant, controlled laboratory settings by skilled personnel.
Innovation Solution
A sample processing tubule with multiple segments containing specific reagents, equipped with an extraction port that allows for controlled processing and harvesting of samples without piercing seals, facilitating multiple processing steps and minimizing contamination, and can be used with or without an analyzer.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional processing devices and methods are used, then sample processing can be performed with high control and precision, but the device complexity and cost increase significantly
Solution Approach 1:
The processing system is divided into discrete segments within a single tubule, each containing specific reagents for different processing steps. This segmentation allows complex processing to occur in a simple, integrated device rather than requiring complex external instrumentation.
Solution Approach 2:
The tubule is designed to perform sample processing autonomously through its internal structure and reagent arrangement. The sample flows through the tubule and undergoes processing steps automatically driven by pressure differentials and reagent interactions, eliminating the need for complex external control systems.
2Reliability
If samples are processed in distant laboratory settings, then proper processing conditions can be maintained, but the time to result and sample integrity are compromised
Solution Approach 1:
All necessary reagents and processing conditions are pre-configured within the tubule structure. The sample can be processed immediately upon collection without requiring transport to a laboratory, as all processing components are already in place within the portable tubule device.
Solution Approach 2:
The tubule integrates multiple processing functions (lysis, washing, neutralization, amplification, detection) into a single portable device that can perform all necessary steps at the point of care, eliminating the need for distant laboratory processing while maintaining proper conditions.
3Manufacturing precision
If intensive processing steps are performed, then sample preparation quality is improved, but the risk of contamination and sample integrity loss increases
Solution Approach 1:
The tubule is divided into separate sealed segments, each containing specific reagents. This physical segmentation prevents cross-contamination between different processing steps while allowing intensive processing to occur within each isolated compartment.
Solution Approach 2:
The tubule structure itself acts as an intermediary barrier between different reagent compartments and the external environment. Seals and barriers within the tubule design prevent contamination while allowing controlled interaction between reagents for intensive processing.
Data Source
Figure 1A~1B
Figure 2A~2B
Figure 2C
AI summary
A sample processing tubule is provided including, from a proximate to a distal end, an opening through which a sample is introducible, at least three segments, and an extraction port operatively connected to a distal segment of the at least three segments. The extraction port enables extraction of a reaction mixture in the distal segment of the tubule without piercing the tubule or one or more seals separating each of the segments in the tubule.