Selective 1224 Production via Phase Transfer Catalysis
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Existing methods for producing 2-chloro-1,3,3,3-tetrafluoropropene (1224) result in significant by-production of 1,2-dichloro-3,3-trifluoropropene (1223), making it difficult to efficiently obtain pure 1224.
Innovation Solution
Contacting 2,3-dichloro-1,1,1,3-tetrafluoropropane (234da) with an inorganic base in an aqueous medium in the presence of a phase transfer catalyst, specifically a quaternary ammonium salt, to suppress the formation of 1223 and enhance the selectivity of 1224 production.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Manufacturing precision
If existing methods are used to produce 2-chloro-1,3,3,3-tetrafluoropropene (1224), then the production process can proceed, but significant by-production of 1,2-dichloro-3,3-trifluoropropene (1223) occurs, reducing manufacturing precision and product purity
Solution Approach 1:
The patent changes the reaction parameters by introducing a phase transfer catalyst and using an inorganic base in an aqueous medium, which fundamentally alters the reaction pathway to suppress by-product formation and enhance selectivity for 1224
Solution Approach 2:
A phase transfer catalyst is introduced as an intermediary substance to facilitate the reaction between 2,3-dichloro-1,1,1,3-tetrafluoropropane and the inorganic base, enabling selective dehydrochlorination while preventing unwanted side reactions that produce 1223
2Productivity
If conventional synthesis methods are employed, then the reaction can proceed, but the yield and purity of 1224 are reduced due to significant by-product formation
Solution Approach 1:
By changing the reaction medium to an aqueous system with inorganic base and adding a phase transfer catalyst, the reaction parameters are optimized to simultaneously increase both the yield and purity of 1224, eliminating the trade-off between productivity and manufacturing precision
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This method effectively reduces the generation of 1223 as a by-product, allowing for high-yield, selective production of 1224, improving the efficiency and purity of the desired product.
Implementation Method 1
bringing 2,3-dichloro-1,1,1,3-tetrafluoropropane (234da) into contact with an inorganic base having a pKa of 4.8 or greater in an aqueous medium in the presence of a phase transfer catalyst
Data Source
AI summary
A production method of 2-chloro-1,3,3,3-tetrafluoropropene (1224) according to the present invention includes bringing 2,3-dichloro-1,1,1,3-tetrafluoropropane (234da) into contact with an inorganic base having a pKa of 4.8 or greater in an aqueous medium in the presence of a phase transfer catalyst. Preferably, the inorganic base has a pKa of 10 or greater. Further, the phase transfer catalyst is preferably at least one selected from the group consisting of tetrabutylammonium bromide, methyltri-n-octylammonium chloride, benzyltrimethylammonium chloride and tetraethylammonium chloride. It is possible by this method to selectively produce 1224 from 234da.