Self-Assembled Complex for Biocompatible Drug Delivery
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Solution Overview
Problem
Existing drug delivery systems face challenges such as toxicity, high costs, and inability to control sustained drug release, often using substances not found in the body.
Innovation Solution
A self-assembled complex composed of substances naturally found in the body, including metal ions and ligands like phosphate or phosphonate, which allows for reversible self-assembly and self-disassembly, enabling controlled release of effective components.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If existing drug delivery systems use substances not found in the body (such as bisphosphonate and synthetic polymers), then delivery efficiency is improved, but toxicity increases
Solution Approach 1:
The patent changes the chemical composition parameters by replacing synthetic substances (bisphosphonate, polyethyleneimine) with biocompatible substances (phosphate, phosphonate, magnesium ions, calcium ions) that exist naturally in the body, thereby reducing toxicity while maintaining delivery functionality
Solution Approach 2:
The patent uses readily available biocompatible substances (phosphate, phosphonate, metal ions) that are naturally present in the body, replacing expensive and potentially toxic synthetic polymers, making the delivery system both safer and more cost-effective
2Duration of action of moving object
If existing drug delivery systems use synthetic polymers and nanoparticles, then sustained release is achieved, but the release period is limited to a short time
Solution Approach 1:
The patent creates a dynamic self-assembled complex that can reversibly assemble and disassemble based on environmental conditions (pH, ion concentration), enabling the system to adapt its release rate and extend the sustained release period through controlled self-disassembly rather than simple degradation
Solution Approach 2:
The patent forms a composite self-assembled complex comprising phosphate/phosphonate ligands and metal ions (magnesium, calcium), creating a new material system with extended release characteristics that overcomes the limitations of single-component synthetic polymers
3Reliability
If existing drug delivery systems use non-biocompatible carriers, then delivery capability is enhanced, but harmlessness to the human body is compromised
Solution Approach 1:
The patent fundamentally changes the material composition parameters by using only substances naturally found in the human body (phosphate, phosphonate, metal ions), transforming the delivery system from potentially harmful synthetic materials to biocompatible natural materials that maintain delivery effectiveness
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The self-assembled complex provides a non-toxic, cost-effective delivery system that can sustainably release drugs or molecules over an extended period, improving biological functions while being harmless to the human body.
Implementation Method 1
one or more metal ions and ligands that are ion-bonded with the metal ion
Implementation Method 2
the self-assembled complex is reversibly self-assembled or self-disassembled, and the self-assembly is performed by any one or more of the concentration of the metal ion and the concentration of the ligand
Data Source
AI summary
The present invention relates to an effective component delivery system using self-assembly and self-disassembly of a self-assembled complex, and the effective component delivery system uses a self-assembled complex which is composed of substances existing in the body, thereby being less toxic and harmless to the human body, and the effective component delivery system is capable of controlling a self-disassembly rate and an effective component release rate by using various kinds of metal ions and ligands including phosphate or phosphonate.