Self-Calibrating Fiber Optic Probe for Real-Time Spectroscopy

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Solution Overview

Problem

Current optical spectroscopy techniques, particularly diffuse reflectance spectroscopy (DRS), face challenges in real-time calibration due to lamp intensity fluctuations and fiber bending losses, leading to significant errors in extracting optical properties from tissue samples, and require lengthy warm-up times and separate calibration procedures, which are not suitable for clinical settings.

Innovation Solution

A self-calibrating fiber optic probe with a built-in calibration channel that generates calibration light simultaneously with illumination light, allowing for real-time correction of spectral data and accounting for fiber bending effects, eliminating the need for separate calibration procedures and reducing delays.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If traditional separate calibration procedures are used to correct lamp intensity fluctuations and fiber bending losses, then measurement accuracy is improved, but measurement time and system complexity increase

Engineering Contradiction:
Improveaccuracy of optical property extractionVSAvoidcalibration time
Core Design Contradiction:
Measurement precisionVSLoss of time

Solution Approach 1:

The patent combines the calibration function and sensing function into a single integrated fiber optic probe. The calibration fiber and sensing fibers are merged into one probe assembly, allowing calibration and measurement to be performed simultaneously without requiring separate calibration procedures or multiple devices.

Inventive Principle:
Principle #5Merging (Combining)

Solution Approach 2:

The calibration channel operates continuously alongside the sensing channel, providing real-time calibration data that accounts for lamp intensity fluctuations and fiber bending effects during the entire measurement process, rather than requiring periodic separate calibration interruptions.

Inventive Principle:
Principle #20Continuity of useful action

2Stability of the object's composition

If a 30-minute warm-up period is used to stabilize lamp intensity, then light intensity stability is improved, but clinical productivity decreases

Engineering Contradiction:
Improvelight intensity stabilityVSAvoidclinical measurement throughput
Core Design Contradiction:
Stability of the object's compositionVSProductivity

Solution Approach 1:

The calibration fiber is pre-configured within the probe assembly with known optical properties, so that calibration data can be obtained immediately upon probe insertion without requiring a warm-up period for lamp stabilization or separate calibration procedures.

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

The system performs self-calibration using the integrated calibration fiber, automatically compensating for lamp intensity variations and fiber bending effects without requiring external calibration equipment or operator intervention for calibration procedures.

Inventive Principle:
Principle #25Self-service

3Measurement precision

If separate calibration procedures using power meters and reflectance standards are performed, then calibration accuracy is improved, but device complexity and operational difficulty increase

Engineering Contradiction:
Improvecalibration accuracyVSAvoidcalibration procedure simplicity
Core Design Contradiction:
Measurement precisionVSEase of operation

Solution Approach 1:

The fiber optic probe performs self-calibration using its own integrated calibration fiber, eliminating the need for external calibration equipment such as power meters and reflectance standards. The system automatically compensates for system variations using the calibration data from the integrated fiber.

Inventive Principle:
Principle #25Self-service

Solution Approach 2:

The single fiber optic probe assembly serves multiple functions: it contains both sensing fibers for measurement and a calibration fiber for calibration, making the device self-sufficient and eliminating the need for separate calibration equipment or procedures.

Inventive Principle:
Principle #6Universality (Multi-functionality)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Enables fast, robust, and systematic real-time calibration of optical spectroscopy, reducing errors caused by lamp intensity fluctuations and fiber bending, and eliminating the need for lengthy warm-up times and separate calibration procedures, making it suitable for clinical applications.

Implementation Method 1

a fiber optic probe with self-calibration capability configured for performing diffuse reflectance spectroscopy

Methodology Applied
Scientific EffectOptical transmission: Optical Fibre

Implementation Method 2

The probe includes a built-in calibration channel that can be used to record the light source spectrum and instrument-fiber responses contemporaneously with tissue spectra measurements

Methodology Applied
Scientific EffectLight generation: Light Emitting Diode

Data Source

PatentUS8804115B2Systems and methods for performing optical spectroscopy using a self-calibrating fiber optic probe
Publication Date: 2014.08.12 DUKE UNIV
  • US8804115B2 patent drawing
  • US8804115B2 patent drawing
  • US8804115B2 patent drawing

AI summary

Systems and methods for performing optical spectroscopy using a self-calibrating fiber optic probe are disclosed. One self-calibrating fiber optic probe includes a sensing channel for transmitting illumination light to a specimen and for collecting spectral data of the specimen. The spectral data includes the illumination light diffusely reflected from the specimen at one or more wavelengths. The self-calibrating fiber optic probe may also include a calibration channel for transmitting calibration light. The calibration light and the illumination light are generated simultaneously from a common light source. The calibration channel collects calibration spectral data associated with the calibration light contemporaneously with the collection of the spectral data of the specimen.