Self-Emulsifying Cannabidiol Formulations for Bioavailability
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Solution Overview
Problem
Existing oral cannabidiol formulations have poor solubility and bioavailability due to their hydroalcoholic and lipid-based formulations, which limits their effectiveness in treating various diseases and disorders.
Innovation Solution
A self-emulsifying cannabidiol composition containing specific surfactants such as polyethylene glycol 40 hydrogenated castor oil, caprylocaproyl polyoxyl-8 glycerides, and alpha tocopherol, which forms an emulsion with an average globule size capable of passing through the gastrointestinal tract, enhancing bioavailability.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If hydroalcoholic or lipid-based formulations are used for oral cannabidiol, then the formulation is easier to administer and improve patient compliance, but the solubility and bioavailability in water (gastrointestinal tract) deteriorates
Solution Approach 1:
The patent changes the physical-chemical parameters of the formulation by incorporating surfactants that alter the solubility characteristics of cannabidiol. The surfactant concentration and type are optimized to achieve micelle formation, transforming the formulation from hydrophobic to amphiphilic, thereby improving aqueous solubility while maintaining oral administrability
Solution Approach 2:
The patent creates a composite formulation system combining cannabidiol with specific surfactants (such as polysorbates, polyoxylglycerides, or castor oil derivatives) in defined ratios. This composite approach leverages the synergistic effects of the components to achieve both oral convenience and improved bioavailability through enhanced solubility
2Reliability
If SEDDS is developed to improve solubilization and bioavailability, then the absorption through lymphatic transport is improved, but the formulation development becomes more complex and time-consuming
Solution Approach 1:
The patent identifies surfactant systems that can serve multiple functions simultaneously: solubilizing cannabidiol, forming stable micelles, facilitating lymphatic transport, and ensuring gastrointestinal stability. This multi-functionality reduces the need for multiple separate formulation components and simplifies the development process
Solution Approach 2:
The patent systematically optimizes key parameters such as surfactant HLB value, concentration ratios, and micelle size to achieve the desired lymphatic transport effect. By establishing parameter ranges and selection criteria, the patent reduces the trial-and-error nature of SEDDS development
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The self-emulsifying composition improves the bioavailability of cannabidiol, allowing for effective treatment of a wide range of diseases and disorders, including epilepsy, schizophrenia, and withdrawal symptoms, by facilitating absorption through the lymphatic system.
Implementation Method 1
Self-Emulsifying Drug Delivery system (SEDDS) have shown to improve solubilization of poorly soluble drugs
Implementation Method 2
comprising from about 40% to about 99% w/w of one or more surfactants selected from polyethylene glycol 40 hydrogenated castor oil, caprylocaproyl polyoxyl-8 glycerides
Implementation Method 3
improve the bioavailability due to reduced first pass metabolism and improved absorption through lymphatic transport by forming chylomicrons
Data Source
AI summary
The present invention is directed to a self-emulsifying cannabidiol composition containing one or more surfactants. The present invention is further directed to a method of treating a disease comprising administering a composition of the present invention to a subject in need thereof. The present invention is further directed to a method of treating withdrawal symptoms.