Self-Emulsifying Skin Composition for Nanoemulsion Delivery
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Solution Overview
Problem
Existing cosmetic and dermatological formulations struggle to effectively penetrate the skin layers, leading to limited efficacy of active substances due to their inability to reach deeper layers, and there is a need for improved carrier systems that enhance skin penetration and bioavailability.
Innovation Solution
A self-emulsifying composition comprising a biosurfactant (surfactin or its salt), a cosurfactant (2-(2-ethoxyethoxy)ethanol or cocamidopropyl betaine), and an oil phase, with specific weight ratios, forms a nanoemulsion that spontaneously emulsifies in water, enhancing skin penetration and encapsulating active substances.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional cosmetic formulations are used, then the formulation is easy to manufacture, but the active substances cannot effectively penetrate the skin layers
Solution Approach 1:
The patent changes the physical-chemical parameters of the formulation by using self-emulsifying systems with specific surfactant-to-oil ratios and molecular characteristics that enable spontaneous penetration through skin layers, transforming conventional formulations into penetrating nanoemulsions
Solution Approach 2:
The patent employs composite self-emulsifying systems combining multiple surfactants (ionic and nonionic), oils, and active substances in specific configurations that create synergistic effects for enhanced skin penetration while maintaining manufacturing feasibility
2Reliability
If surfactants are used to create carriers for encapsulation, then the bioavailability of hydrophobic substances increases, but the formulation complexity increases
Solution Approach 1:
The patent utilizes self-emulsifying systems that automatically form encapsulation carriers upon contact with skin or aqueous environments, eliminating the need for complex external emulsification equipment or multi-step processing while achieving effective encapsulation of hydrophobic active substances
Solution Approach 2:
The patent exploits phase transition phenomena where the formulation transitions from a separated state to a self-emulsified nanoemulsion state upon contact with water or skin, enabling spontaneous formation of encapsulation structures without complex manufacturing processes
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The nanoemulsion demonstrates good skin penetration capacity, allowing for effective delivery of encapsulated substances, as evidenced by its small particle size and Zeta potential, and is suitable for use in the cosmetic industry.
Implementation Method 1
Biosurfactants, which are compounds that lower the surface tension, are extracellular metabolites produced by bacteria, yeasts or moulds
Implementation Method 2
Self-emulsifying systems are isotropic systems consisting of a surfactant, a cosurfactant and an oil phase which, when diluted in the appropriate ratio, spontaneously self-emulsify
Data Source
AI summary
The self-emulsifying composition, intended for administration onto the skin, contains a biosurfactant, a cosurfactant and an oil phase. The weight ratio of the bio surfactant, the cosurfactant and the oil phase is 0.01-96.99% by weight:0.01-96.99% by weight:3-70% by weight, respectively, where the bio surfactant is surfactin or its salt, and the cosurfactant is 2-(2-ethoxyethoxy)ethanol or cocamidopropyl betaine.