Self-hardening bone cement using partially deacetylated chitin

Resolve Bottlenecks,
Find Innovative SolutionsGenerate Solutions

Solution Overview

Problem

Current bone graft substitutes lack both osteoconductive and osteogenic properties necessary for effective bone healing, and existing technologies for bone autografts are morbid and inefficient.

Innovation Solution

Development of injectable, self-hardening bioactive bone cement compositions using partially deacetylated chitin polymers with a degree of deacetylation between 40-75%, which provide osteogenic stimulation and antimicrobial properties, allowing for minimally invasive application and promoting bone regeneration.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If bone autograft is used to fill bone voids, then osteoconductive and osteogenic properties are provided, but morbidity associated with bone harvest occurs

Engineering Contradiction:

Improvebone healing effectivenessVSAvoidmorbidity from bone harvest

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent extracts the essential functional properties (osteoconductive and osteogenic) from the bone autograft and transfers them to a synthetic bone graft substitute composed of PDC and calcium phosphate, eliminating the need for bone harvest while maintaining therapeutic effectiveness

Inventive Principle:

Principle #2Taking out (Extraction)

Solution Approach 2:

The invention creates a composite material system combining partially deacetylated chitin (PDC) with calcium phosphate to synthesize a bone graft substitute that replicates the dual osteoconductive and osteogenic properties of natural bone autografts

Inventive Principle:

Principle #40Composite materials

2Reliability

If conventional chitosan with 75-100% degree of deacetylation is used, then solubility control is achieved, but osteogenic properties are insufficient

Engineering Contradiction:

Improveosteogenic propertyVSAvoidsolubility range

Core Design Contradiction:

ReliabilityVSAdaptability or versatility

Solution Approach 1:

The patent changes the degree of deacetylation parameter from the conventional 75-100% range to a lower 40-75% range, creating PDC with optimized solubility and enhanced osteogenic properties that conventional chitosan cannot achieve

Inventive Principle:

Principle #35Parameter changes

3Ease of operation

If injectable bone cement is used for minimally invasive application, then ease of operation is improved, but control over setting time and leakage is challenging

Engineering Contradiction:

Improveminimally invasive applicationVSAvoidsetting time control

Core Design Contradiction:

Ease of operationVSManufacturing precision

Solution Approach 1:

The patent incorporates calcium phosphate particles into the PDC matrix in advance, creating a pre-formulated composite that sets predictably upon injection without requiring additional components or complex mixing procedures

Inventive Principle:

Principle #10Preliminary action

Solution Approach 2:

The PDC-calcium phosphate composite exhibits self-hardening properties upon injection, automatically setting in situ without requiring external catalysts or complex activation mechanisms, thereby simplifying the application process

Inventive Principle:

Principle #25Self-service

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The compositions offer effective bone regeneration with good biocompatibility, antimicrobial properties, and the ability to fill bone voids without leakage, promoting new bone tissue formation and minimizing infection risk, while being suitable for clinical use with optimized mechanical strength and handling characteristics.

Implementation Method 1

partially deacetylated chitin polymers with a degree of deacetylation between 40-75%, which provide osteogenic stimulation and antimicrobial properties, allowing for minimally invasive application and promoting bone regeneration

Methodology Applied

Scientific EffectOsteogenic stimulation:

Implementation Method 2

partially deacetylated chitin polymers with a degree of deacetylation between 40-75%, which provide osteogenic stimulation and antimicrobial properties

Methodology Applied

Scientific EffectAntimicrobial properties:

Implementation Method 3

injectable, self-hardening bioactive bone cement compositions

Methodology Applied

Scientific EffectSelf-hardening:

Data Source

PatentEP2841114B1Self-hardening bioactive cement compositions with partially deacetylated chitin as bone graft substitutes

Publication Date: 2018.06.13 GENIS EHF

Figure 1~2
Figure 3
Figure 4

AI summary

A composition kit for bone healing medical treatment, comprising partially deacetylated chitin (PDC) with a degree of deacetylation in the range of 40-75%. The composition is provided as a kit with a solids fraction and a liquid fraction, provided in separate vials and to be mixed just prior to use. The weight: weight ratio of the solids to liquid fraction is in the range from 1:1.2 to 1:6, and preferably from 1:1.5 to 1:4. The solids fraction comprises the PDC material and calcium phosphate and the liquid fraction comprises water and an acid.