Semifluorinated Alkane Tamponade Composition for Retinal Visual Acuity
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Solution Overview
Problem
Current tamponade agents for treating retinal detachment, such as silicone oils, cause visual acuity issues due to mismatched refractive indices and emulsification, leading to the need for corrective lenses and decreased vision during treatment.
Innovation Solution
A composition comprising a mixture of semifluorinated alkanes with a refractive index of 1.310 to 1.365, closely matching the natural vitreous body's refractive index, to minimize emulsification and improve visual acuity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If silicone oils are used as tamponade agents, then the retina can be effectively tamponaded, but visual acuity decreases and corrective lenses are required due to refractive index mismatch
Solution Approach 1:
The patent changes the refractive index parameter of the tamponade agent by using semifluorinated alkanes (refractive index 1.310-1.365) instead of traditional silicone oils (refractive index ~1.400), bringing it closer to the natural vitreous body's refractive index and thereby improving visual acuity during treatment
Solution Approach 2:
The patent employs composite material strategy by creating a mixture of semifluorinated alkanes with specific physical properties that combine both effective tamponade capability and optimal refractive index matching, achieving dual functionality
2Reliability
If traditional tamponade agents are used, then retinal detachment can be treated, but emulsification occurs leading to treatment complications
Solution Approach 1:
The patent modifies the chemical composition parameters by selecting semifluorinated alkanes with specific molecular structures and physical properties (refractive index 1.310-1.365, appropriate viscosity) that inherently resist emulsification with aqueous media, thereby improving compositional stability
Solution Approach 2:
The patent employs materials that are biocompatible and can be safely absorbed or removed without causing long-term emulsification issues, treating the tamponade agent as a temporary solution that does not persist problematically in the eye
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition reduces the need for visual acuity correction and minimizes emulsification, providing a more user-friendly treatment for retinal detachment by maintaining refractive stability within the eye.
Implementation Method 1
The refractive index of the composition is from about 1.310 to about 1.365, closely matching the natural vitreous body's refractive index
Implementation Method 2
The tamponade agent is an immiscible liquid, especially with aqueous media/liquids, which prevents retinal breaks due to its interfacial tension and buoyancy
Implementation Method 3
The tamponade agent is an immiscible liquid, especially with aqueous media/liquids, which prevents retinal breaks due to its interfacial tension and buoyancy
Data Source
Figure 1A~1E
Figure 1F~1I
Figure 2A~2B
AI summary
The present invention inter alia relates to a composition comprising a mixture of at least one oil and one or more semifluorinated alkanes, the refractive index of the composition being from about 1.310 to about 1.365, and to a use of said composition for treating a disease, wherein the disease optionally comprises treating a detached retina. The invention also relates to a kit of parts comprising the composition, and to a method of producing the composition.