Oil-in-Water Semiochemical Emulsion for Stable Topical Delivery
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Solution Overview
Problem
Existing semiochemical formulations face challenges due to physico-chemical constraints such as volatility and insolubility in water, necessitating the development of non-toxic and environmentally friendly aqueous formulations for topical application, particularly to prevent pests and parasites on animal and human skin.
Innovation Solution
A stable and homogeneous oil-in-water emulsion comprising an aqueous phase with humectants and gelling agents, and an oily phase with emollients and semiochemicals, such as 3-cyclopentyl propionic acid and bis(2-ethylhexyl) adipate, is developed for topical application.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If semiochemical formulations are used to prevent pests and parasites, then protection effectiveness is improved, but toxicity and environmental harm increase due to reliance on excipients like ethoxydiglycol
Solution Approach 1:
The patent changes the chemical composition parameters by replacing toxic excipients (ethoxydiglycol) with natural alternatives (humectants like glycerol, sugars, and gelling agents like polysaccharides). This parameter change maintains the protective function while eliminating harmful effects, achieving both reliability improvement and harmful factor reduction.
Solution Approach 2:
The patent employs biodegradable, natural excipients that are environmentally friendly and can be safely disposed of or degraded naturally. These replacement excipients (humectants and gelling agents) are non-toxic and environmentally benign, contrasting with the persistent synthetic excipients like ethoxydiglycol that caused environmental harm.
2Object-generated harmful factors
If semiochemical compounds are formulated in aqueous systems, then environmental friendliness and non-toxicity are improved, but formulation stability and homogeneity deteriorate due to volatility and insolubility
Solution Approach 1:
The patent introduces humectants and gelling agents as intermediary substances that mediate between the aqueous phase and semiochemical compounds. These intermediaries improve the solubility and stability of semiochemicals in water-based formulations, preventing volatility and phase separation while maintaining environmental friendliness.
Solution Approach 2:
The patent creates a composite aqueous formulation combining multiple components: water, humectants (polyols and sugars), gelling agents (polysaccharides), and semiochemical compounds. This composite system achieves both stability and homogeneity while maintaining environmental friendliness, resolving the contradiction between formulation performance and ecological safety.
3Reliability
If existing excipients like ethoxydiglycol are used in semiochemical formulations, then product performance is maintained, but regulatory compliance and public acceptance deteriorate due to synthesis methods and toxicity concerns
Solution Approach 1:
The patent replaces synthetic excipients with natural, biodegradable alternatives that are easier to manufacture sustainably and more acceptable to regulators and consumers. The natural humectants and gelling agents eliminate concerns about synthetic excipient toxicity and environmental persistence, improving regulatory compliance and public acceptance while maintaining product performance.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The emulsion provides effective prevention of invertebrate settlement and bites, while being compliant with regulatory standards and environmentally friendly, maintaining stability over time and temperature variations.
Implementation Method 1
a composition in the form of an oil-in-water emulsion comprising: a) an aqueous phase comprising water, at least one humectant chosen from polyols and sugars, and at least one gelling agent chosen from polysaccharides, b) an oily phase comprising at least one emollient agent, at least one emulsifying agent, and a semiochemical composition
Data Source
AI summary
The invention relates to the field of semiochemical products, and describes in particular a composition in the form of an oil-in-water emulsion comprising an aqueous phase and an oily phase comprising a semiochemical composition, particularly suitable for being administered in particular in the form of a milk, as well as its preparation process. The invention also relates to the non-therapeutic use of the composition according to the invention for topical, in particular cutaneous, administration to an animal or human.